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咖啡酸苯乙酯合成的改进 被引量：2

Improvement on Synthesis of Caffeic Acid Phenethyl Ester
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摘要 以米氏酸、2-苯乙醇和3,4-二羟基苯甲醛为原料,甘氨酸为催化剂,N,N-二甲基甲酰胺(DMF)为助溶剂,甲苯为溶剂,经Knoevenagel缩合反应一锅法合成了目标化合物(CAPE),收率为85.0%(以3,4-二羟基苯甲醛计),纯度99.1%(HPLC法)。 Caffeie acid phenethyl ester was synthesized from isopropylidene malonate,2-phenylethanol and 3,4-dihydroxybenzaldehyde by Knoevenagel-Doebner condensation with the catalysis of glycine in one-pot. The yield of CAPE was 85.0% based on 3,4- dihydroxybenzaldchyde and the purity was 99.1% （HPLC）.
作者 黎常魁 曾庆友
机构地区 华侨大学生物医学学院 华侨大学化工学院
出处 《化学试剂》 CAS 北大核心 2016年第5期485-487,共3页 Chemical Reagents
基金 中央高校基本科研业务费国家自然科学基金培育计划项目(JB-ZR1153)
关键词 咖啡酸苯乙酯 KNOEVENAGEL缩合 甘氨酸 一锅法合成 coffeic acid phcnyl ester Knoevenagel condensation glycine one-pot synthesis
分类号 TQ463 [化学工程—制药化工]
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参考文献18

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二级参考文献75

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化学试剂
2016年 第5期

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