纳豆激酶分子结构与潜在应用价值分析

A Review on the Molecular Structure of Nattokinase and Its Potential Application

纳豆激酶因具有较强的溶血能力而著称。目前国内外大量研究人员聚焦于纳豆激酶研究,其开发利用已经获得了长足发展,但同时许多问题与不足也随之暴露出来。一方面是对纳豆激酶的开发利用大多局限于溶栓活性的利用与开发,低估了纳豆激酶应有的整体价值;其次是针对该酶开发和利用的方法过于传统,尚未形成组学大数据和生物信息学技术相结合的探索思维。因此,需要利用更为开阔的研究思路和开发手段来实现纳豆激酶开发利用的最大化。作者从纳豆激酶分子水平和家族分类层次上系统地阐述该酶分子特征,同时对纳豆激酶家族蛋白酶的应用现状进行分析,并对纳豆激酶研发前景进行了展望。

Nattokinase （NK） is well known for its strong thrombolytic property. However, methods for exploring the enzyme are still traditional and its value is thus underestimated. In this review, the structure and the classification for NK were summarized. Based on the applications of NK family proteases, the potential utilizations of NK were predicted.