癫痫患者服用卡马西平对颈动脉内中膜厚度的影响

Influence of epileptic patients took carbamazepine for carotid artery intima-media thickness

目的研究癫痫患者服用卡马西平对颈动脉内中膜厚度(carotid artery intima-media thickness,CA-IMT)的影响。方法选择2012-05—2014-05在我院接受治疗的癫痫患者84例,根据随机数字法分成口服卡马西平组42例(A1组)及癫痫未治疗组(A2组),另选同期在我院接受健康体检的志愿者42例为对照组(B组),对比各组血脂、Hcy及CRP水平,各组CA-IMT水平,分析影响CA-IMT水平的危险因素。结果 A1组TC、TG、LDL-C、Hcy及CRP水平均分别显著高于A2组及B组,差异均有统计学意义(均P<0.05)。A1组右侧CA-IMT、左侧CA-IMT及平均CA-IMT水平均分别显著高于A2组及B组,差异均有统计学意义(均P<0.05)。Logistic回归分析显示,用药时间及用药总剂量均为影响CA-IMT水平的危险因素。结论癫痫患者经卡马西平治疗对血脂水平具有一定的影响,同时还可增加CA-IMT水平,值得临床应用时关注。

Objective To study influence of epileptic patients took carbamazepine for carotid artery intima-media thickness （CA-IMT）. Methods The study was performed on 84 patients with epilepsy from May 2012 to May 2014 treated in our hospi- tal. According to the figures were randomly divided into carbamazepine group 42 cases （group A1）and epilepsy untreated group （group A2）, 42 cases of healthy volunteers were chose as control group （group B）, the serum lipids, Hcy and CRP level, CA -IMT level of each group were compared, and the risk factors of CA-IMT level were analyzed. Results The A1 group＇s TC, TG, LDL-C, Hey and CRP levels were significantly higher than those of A2 group and B group, the difference was statistically significant （P^0.05）. Group Al＇s right CA-IMT, left CA-IMT and average CA-IMT levels were significantly higher than the A2 group and B group, the differences were statistically significant （P〈0.05）. Logistic regression analysis showed that, the using time and total dose effects of medication were risk factors of CA-IMT level. Conclusion Patients with epilepsy after carbamazepine treatment has a certain effect on the serum lipid level, also can increase the levels of CA-IMT in patients; it is worth of clinical application.