用无溶剂法制备二芳基磷氧化物的合成研究

The Study for the Synthesis of Phosphine Betti Base by Three Components Condensation under Solvent-Free Conditions

以β-萘酚,苯甲醛和二苯基氧磷为原料,一水合对甲基苯磺酸作有机酸作为催化剂,采用一锅法合成新的二芳基磷氧化物.结果表明,β-萘酚,苯甲醛和二苯基氧磷的三组分合成在高温无溶剂的条件中能够得到目标产物,该合成方法高效简单.

A simple and efficient procedure has been developed for the preparation of diarylmethyl phosphine oxides by us- ing p-toluenesulfonic acid monohydrate as an organic acid catalyst. The methodology involved the one-pot condensation re- action of β-naphthol and aryl aldehydes and diphenylphosphine oxide under solvent-free conventional heating conditions. The present approach offered several advantages such as shorter reaction times, simple work-up, excellent yields and low- cost catalyst.