缺氧诱导因子-1α在子宫内膜异位症患者子宫内膜的表达及意义

The Expression of Hypoxia Inducible Factor-1α in the Endometrium of Patients with Endometriosis

目的：观察分析缺氧诱导因子‐1α（HIF‐1α）在子宫内膜异位症（简称内异症）患者子宫内膜细胞的表达及意义。方法：收集不同r‐A FS分期子宫内异症患者（内异症组，n＝35）和同期子宫肌瘤患者（对照组，n＝40）子宫内膜组织标本，应用免疫组织化学（SP）技术检测各组（期）HIF‐1α的表达情况，分析组间差异及与r‐AFS分期的相关性。结果：子宫内异症组异位、在位子宫内膜HIF‐1α阳性表达率分别为82．86％和77．14％，均明显高于对照组子宫内膜（52．50％）（χ2＝7．741、4．920，P均＜0．05），且子宫内异症组子宫内膜 HIF‐1α阳性表达率随r‐AFS分期提高而升高（ r＝0．363，P＜0．05）。结论：H IF‐1α表达上调可能与子宫内异症的发生发展有关。

Objective：To study the expression of hypoxia inducible factor‐1αprotein in the endometrium of pa‐tients with endometriosis .Method：The specimens were gathered from endometrium of 35 patients with endometrio‐sis and 40 cases with hysteromyoma as control group .35 cases with the endometriosis were staged according to the revised American Fertility Society System .Immunohistochemistry SP method was performed to examine the expres‐sion of hypoxia inducible factor‐1α protein in the endometrium and the results were analyzed statistically .Results：The positive rates of hypoxia‐inducible factor‐1αprotein in ectopic and eutopic endometria tissue were 82 .86% and 77 .14% respectively ,which were significantly higher than that in control group （52 .50% ） .There were statistical differences between the expression of hypoxia‐inducible factor‐1αprotein in ectopic and eutopic endometria tissue and that in control group （χ2 =7 .741 ,χ2 =4 .920 ,P〈0 .05） .The expression of hypoxia‐inducible factor‐1αprotein was significantly positively correlated with r‐AFS stage （r=0 .363 ,P〈0 .05） .Conclusion：The up‐regulation of hypoxia‐inducible factor‐1αprotein expression was possibly relevant to the development of the endometriosis .