两种透析方法治疗终末期糖尿病肾病前后患者血管内皮生长因子和基质金属蛋白酶-9水平变化

Effect of Two Dialysis Methods on MMP-9 and VEGF Levels in Diabetic Patients with End-Stage Renal Disease

目的:分析两种透析方法对终末期糖尿病肾病(ESDN)患者血清血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)水平的影响及临床意义。方法:80例ESDN患者,按照随机数字表法分为观察组(n=40)和对照组(n=40)。观察组采用维持性血液透析,对照组采用不卧床持续腹膜透析,均治疗6个月。观察两组患者治疗前后血压(BP)、血清白蛋白(SA)、血红蛋白(Hb)、VEGF、MMP-9水平变化和不良反应。结果:治疗前,两组患者上述各项指标差异均无统计学意义(P均>0.05);治疗后,观察组上述各项指标较治疗前明显改善(P<0.05或P<0.01);对照组除SA、Hb外,其它指标均较治疗前好转(P<0.05或P<0.01)。观察组治疗后各项指标改善明显好于对照组(P<0.05或P<0.01)。两组不良反应发生率差异无统计学意义(P>0.05)。结论:ESDN患者透析治疗可优先选择持续性血液透析。

Objective：To investigae effect of two dialysis methods on MMP‐9 and VEGF levels in diabetic pa‐tients with end‐stage renal disease .Method：80 cases of diabetic nephropathy patients ,according to the random num‐ber table method divided into observation group （40 cases） and control group （40 cases） ,the observation group was given continuous hemodialysis ,and the control group was given continuous ambulatory peritoneal dialysis .The changes of systolic blood pressure ,diastolic blood pressure ,serum albumin ,hemoglobin ,VEGF and MMP‐9 were observed before and after treatment in two groups ,and the adverse reactions were recorded .Results：Before treat‐ment ,differences in the above indexes of two groups had no statistical significance （P＆gt;0 .05）;after treatment ,ob‐servation group the various indicators improved significantly compared with those before treatment （P〈0 .05 or P〈0 .01）;control group except for SA ,Hb and other indicators were compared with those before treatment improved （P〈0 .05 or P〈0 .01） .In the observation group after treatment ,the improvement of the indicators was signifi‐cantly better than the control group （P〈0 .05 or P〈0 .01） .The adverse reaction rate had no significant difference in two groups （P〉0 .05） .Conclusion：Patients with end‐stage diabetic nephropathy may be preferentially selected for continuous hemodialysis .