黄花角蒿的化学成分研究

Chemical constituents from Incarvillea sinensis var. przewalskii

目的对黄花角蒿Incarvillea sinensis var.przewalskii全草的化学成分进行研究。方法采用正相硅胶、凝胶Sephadex LH-20以及半制备高效液相色谱等多种色谱技术进行分离纯化,运用NMR、MS等波谱学方法以及结合文献数据对分离得到的化合物进行结构鉴定。结果从黄花角蒿全草80%乙醇水溶液提取物中分离得到13个化合物,包括生物碱和苯乙醇苷类化合物,其结构分别鉴定为对丁氧基红景天苷(1)、角蒿辛C(2)、角蒿酯碱(3)、7-羟基多花藤碱(4)、角蒿原碱(5)、苯乙醇葡萄糖苷(6)、地黄苷(7)、类叶升麻苷(8)、去酰基异角胡麻苷(9)、去咖啡酰基类叶升麻苷(10)、carceorioside B(11)、红景天苷(12)、去酰基类叶升麻苷二甲醚(13)。结论化合物1为新化合物,其他化合物均为首次从该植物中分离得到。

Objective To investigate the chemical constituents from the whole plant of Incarvillea sinensis var. przewalskii, and a systematically phytochemical investigation was carried out. Methods The chemical constituents were isolated by column chromatographies, such as silica gel and Sephadex LH-20 columns as well as semi-preparative HPLC, and their structures were determined on the basis of MS, NMR spectroscopic analyses, and/or comparison with literature data. Results Thirteen compounds, including alkaloids and phenylethanoid glycosides, were isolated from the 80% ethanol extract of the whole plants. Their structures were elucidated as p-butoxyl-salidroside （1）, incasine C （2）, incarvillateine （3）, 7-hydroxyskytanthine （4）, incarvilline （5）, phenethylalcohol glucoside （6）, martynoside （7）, acteoside （8）, deacylisomartynoside （9）, decaffeoylacteoside （10）, carceorioside B （11）, salidroside （12）, and deacylacteoside dimethyl ether （13）. Conclusion Compound 1 is a new one, and the other compounds are isolated from this species for the first time.