摘要
目的优选适宜亲水性物质释放的热熔压敏胶基质的配比。方法采用正交试验法,以胶体的黏性、亲水性药物的释放度为指标,以C_5石油树脂、以苯乙烯-异戊二烯-苯乙烯(SIS)、丙烯酸乙酯-甲基丙烯酸甲酯-甲基丙烯酸氯化三甲胺基乙酯共聚物(RLPO)、液体石蜡、邻苯二甲酸二辛酯(DOP)、聚乙二醇400(PEG 400)、抗氧化剂1010为材料,筛选热熔压敏胶基质的配方。结果最佳基质配比为SIS-C_5石油树脂-RLPO-液体石蜡-PEG 400-DOP-抗氧化剂1010为3∶4∶6∶6∶5∶1∶0.1,所制得的热熔压敏胶黏性适宜,对亲水性药物释放度高。结论本研究制备的热熔压敏胶是制备亲水性药物经皮给药贴剂的良好材料。
Objective To optimize the matrix proportion of SIS hot melt pressure sensitive adhesive suit for hydrophilic material releasing. Methods By orthogonal test method, taking adhesiveness and hydrophilic drug release rate as factors, and C5 petroleum resin hydrogenate, lanoline styrene-isoprene-styrene （SIS） triblock copolymer, ethyl acrylate-methyl methacrylate-trimethylamino （RLPO）, liquid paraffin, dibutyl phthalate （DOP）, polyethylene glycol （PEG） 400, and Antioxidant 1010 as materials, the matrix proportion was optimized. Results The optimized formulation was as follows： SIS-C5 petroleum resin hydrogenate-SIS-RLPO-DOP-PEG 400-Antioxidant 1010 was 3 ： 4 ： 6 ： 6 ： 5 ： 1 ： 0.1. The adhesiveness was proper and shows more release rate for hydrophilic material. Conclusion The SIS hot melt pressure sensitive adhesive shows good property and is suitable to prepare transdermal patch.
出处
《中草药》
CAS
CSCD
北大核心
2016年第5期748-751,共4页
Chinese Traditional and Herbal Drugs
基金
河南省教育厅科学技术研究重点项目资助计划(14A360011)
