血内脂素、尿酸水平与慢性肺源性心脏病及心肺功能相关性研究

The relationships among blood visfatin,blood uric acid levels and cardiopulmonary function in patients with chronic pulmonary heart disease

目的探讨血内脂素及尿酸对慢性肺源性心脏病患者心、肺功能的影响及相关性。方法选取我院呼吸内科收治的慢性肺源性心脏病患者90例为观察组(肺心病组),其中NYHA心功能分级Ⅱ级、Ⅲ级、Ⅳ级各30例。选择同期来我院健康体检者40例为对照组。检测两组受试者血内脂素及尿酸水平,并检测肺心病患者血氧分压、肺功能,对检测结果进行统计学分析。结果肺心病组血内脂素水平明显高于对照组,差异具有统计学意义(P均<0.001)。随着心功能级别的升高,血内脂素水平逐渐升高,心功能Ⅱ级与Ⅲ级、Ⅳ级比较,其内脂素水平差异有统计学意义(P均<0.05),心肺功能下降与血内脂素水平呈正相关(r=0.827,P<0.05),表明血内脂素水平与慢性肺源性心脏病密切相关。此外,肺心病组血尿酸水平明显高于对照组,差异具有统计学意义(P均<0.05);心功能Ⅱ级与Ⅲ级、Ⅳ级的血尿酸水平差异有统计学意义(P<0.05),且心肺功能下降与血尿酸水平呈正相关(r=0.806,P<0.05)。结论血内脂素水平及尿酸含量的监测对慢性肺源性心脏病患者的诊治有重要参考意义。

Objective To assess the effects of blood visfatin and uric acid on cardiopulmonary function in patients with chronic pulmonary heart disease and their correlations. Methods Ninety patients with pulmo- nary heart disease who were cared at Respiratory Medicine Department of our hospital were selected as an ob- servation group,30 of them got NYHA class II , 30 of them got NYHA class III, 30 of them got NYHA class IV. At the same time,45 healthy controls were selected from Health Examination Center. The blood visfatin and uric acid levels were detected in the two groups,and artery blood oxygen partial pressure and dardiopulmo- nary function level were detected in observation and control groups,all date were analyzed statistically. Results Comparing the observation group to the control group showed that the blood visfatin levels in the obser- vation group were much higher. There were all statistically significant difference （all P 〈0. 05）. The higher the cardiac function was, the greater the blood visfatin elevated. The blood visfatin levels of NYHA class III and IV groups were higher than that of NYHA class II group, and the differences had statistical significances （all P 〈0.05）. The further stepwise multivariate logistic regression analysis showed that the decrease of pul- monary heart function had positive linear correlation with blood visfatin level （ r = 0.827, P 〈0.05）, the data suggested that blood visfatin level was closely correlated with chronic pulmonary heart disease. Moreover, the levels of blood uric acid in the observation group were much higher than that in the control group, and the differences had statistical significance （all P 〈0.05）. A comparison of uric acid level between NYHA class II group and NYHA class III and IV groups showed statistically significant differences （ P〈0.05）. The decrease of pulmonary heart function had positive linear correlation with blood uric acid level （ r =0. 806, P 〈0.05）. Conclusion Monitoring the level of blood visfatin and uric acid concentration has important references in diagnosis and treatment of chronic pulmonary heart disease.