枸地氯雷他定联合胸腺肽治疗慢性特发性荨麻疹的疗效及对T细胞亚群的影响研究

The curative outcomes of Desloratadine Citrate combined with thymic peptide in treatment of chronic idiopathic urticaria and the effects on T lymphocyte subgroup

目的观察采用枸地氯雷他定联合胸腺肽治疗慢性特发性荨麻疹的疗效及对T细胞亚群的影响。方法选取172例慢性特发性荨麻疹患者为研究对象,随机分成对照组(n=82)和观察组(n=90),观察组联用枸地氯雷他定片和胸腺肽肠溶片,对照组单用枸地氯雷他定片,两组患者均治疗4周;记录治疗前后瘙痒程度、风团数目等,对比分析两组患者的治疗效果及治疗4周后外周血T细胞亚群的变化。结果治疗后观察组皮肤瘙痒程度、风团数目、UAS评分改善效果明显优于对照组(P<0.05),观察组总有效率为92.22%,对照组总有效率为73.17%,两组间疗效比较差异有统计学意义(P<0.001)。治疗后治疗组与对照组相比,CD4+水平升高,CD8+水平降低,CD4+/CD8+比值明显升高,差异均有统计学意义(P<0.001)。结论慢性特发性荨麻疹采用枸地氯雷他定联合胸腺肽治疗,疗效显著,能明显改善患者的临床症状及提高细胞免疫功能。

Objective To evaluate the efficacy of Desloratadine Citrate combined with thymic peptide in treatment of chronic idiopathic urticaria and the effects on T lymphocyte subgroup. Methods A total of 172 chronic idiopathic urticaria patients were randomly allocated into observation group （ n =90） and control group （ n =82）. All patients were treated with Desloratadine Citrate tablets with regular dose for 4 weeks, and pa- tients in the observation group were added with thymic peptide for 4 weeks. Degree of pruritus and the wheal number were recorded. Patients were evaluated by using the urticaria activity score （UAS） before and after treatment, the efficacy and levels of T lymphocyte subsets of the two groups were compared and analyzed. Results After treatment, the improvement of skin pruritus, wheal number, and UAS in the observation group were better than those of the control group （ P 〈0.05）. The total efficacy of 92.22% in the observation group was significantly higher than that of 73.17% in the control group, comparison of the efficacy between the two groups showed statistically significant difference （ P 〈0. 001）. After treatment, comparison the observation group with the control group, CD4^＋ level elevated, CD8^＋ level decreased, the ratio of CD4^＋/CD8^＋ elevated significantly in the observation group, there were statistically significant differences （ P 〈0. 001）. The combination of Desloratadine Citrate and thymic peptide in the treatment of chronic idiopathic obviously effective for reducing disease symptoms and improving cell immunologic function.