健脾清肠方对溃疡性结肠炎患者生活质量作用的随机对照试验（英文）

Effects of Jianpi Qingchang Decoction on the quality of life in patients with ulcerative colitis: A randomized controlled trial

目的:探讨健脾清肠方(JQD)对脾虚湿热证型溃疡性结肠炎(UC)患者生活质量的影响。方法:120例脾虚湿热证型活动期UC患者,随机分为试验组(60例)与对照组(60例),分别予以JQD、5-ASA治疗。治疗8周后,评价2组患者在炎症性肠病生活质量问卷(IBDQ)、健康调查简表(SF-36)积分、Sutherand DAI积分、证候与症状疗效方面的差异,并以此来评价患者的生活质量。结果:治疗后,两组的Sutherand DAI积分均有下降(P<0.01),但两组间比较差异无统计学意义。治疗后两组患者在IBDQ量表的肠道症状、全身症状的维度及总分,SF-36量表的生理机能、躯体疼痛、精力、精神健康4个维度及总分,腹痛、乏力的临床症状改善方面均有显著性差异(P<0.05,P<0.01)。结论:JQD可以作为一种补充和替代疗法治疗轻-中度活动期脾虚湿热型UC,并可以改善患者的生活质量。

To determine the effects of the Jianpi Qingchang Decoction（JQD） on the quality of life（QOL） in ulcerative coltis（UC） patients with spleen deficiency and dampness-heat syndrome. Methods： A total of 120 active UC patients with spleen deficiency and dampness-heat syndrome, were selected and randomly divided into test and control groups, 60 cases in each group. Patients in the test group were treated with JQD, while patients in the control group were treated with 5--aminosalicylic acid（5--ASA）. After treatment for 8 weeks, the differences in the IBDQ, SF--36 score, Sutherland DAI score and clinical symptoms were compared between the two groups to assess the QOL of patients. Results： The Sutherland DAI score decreased for both the groups after the treatment（P〈0.01）, but the difference was not statistically significant between two groups. However, the two groups were significantly differenced with respect to the bowel symptoms, systemic symptoms and total score of IBDQ, four dimensions of SF--36, including physical functioning, bodily pain, vitality, and mental health, total score, and the clinical symptoms of abdominal pain and weakness（P〈0.05, P〈0.01）. Conclusion： JQD can be used as supplementary and alternative therapy to relieve clinical symptoms of patients with mild to moderate active UC in the syndrome of spleen deficiency and dampness-heat, and consequently improve their QOL.