超声及微泡介导的基因载体的进展

Advances in ultrasound and microbubble mediated gene carrier

超声及微泡辅助基因传递正在迅速发展,其中,超声起着触发转染的"扳机点"作用,微泡作为能量的聚焦点亦不可或缺。基因转染成功的关键在于通过载体将基因安全高效地传递到靶器官。从最初超声辅助质粒转染发展到超声与脂质体-质粒联合介导转染,超声及微泡介导的基因载体经历了近三十年的发展。本文就超声及微泡介导的基因转染及基因载体的最新进展做一综述。

Ultrasonic and microbubble assisted gene delivery is booming now. Ultrasound plays a role of the trigger point in triggering the transfection and microbubbles, as the focal point of energy, is also indispensable. The success of gene transfection depends on an efficient and safe carrier system that deliveries genetic material into target organ. From initial ultrasound assisted plasmid transfection to ultrasound associated liposome-plasmid mediated gene transfection, ultrasound and microbubble mediated gene carrier has been developed for nearly thirty years. This artical reviewed the recent advances in ultrasound and microbubble mediated gene transfection and gene can＇ier.