N-乙酰半胱氨酸对心脏等重要脏器作用的研究进展

Research progress of effect of N-acetylcysteine on heart and other important organs

N-乙酰半胱氨酸具有抗氧化,抗凋亡等作用。可以通过自身的活性巯基(-SH)参与氧化反应,增加细胞内还原型谷胱甘肽(GSH)含量,清除自由基,调节细胞代谢等作用。它可以改善心功能,延缓心室重构,减轻肺损伤、改善肺功能,减轻酒精等对肝细胞的损伤,还能减轻造影剂对肾组织的损伤。广泛应用于临床、动物实验等研究,在心、肺、肝、肾等重要脏器都能发挥抗氧化,减轻细胞损伤等作用。

N-acetylcysteine has anti oxidation, anti apoptosis and so on. It can participate in the oxidation reaction by the active thiol group （-SH）, and increase the content of glutathione （GSH）, scavenge free radicals, regulate cell metabolism and so on. It can improve cardiac function and delay the ventricular remodeling; reduce lung injury, im- prove lung function; reduce the damage of alcohol on the liver cells; and also can reduce the contrast agent on renal tissue damage. It is widely used in clinical, animal experiments and other research, playing the role of anti oxidation, reducing cell damage in the heart, lungs, liver, kidney and other important organs.