摘要
阿尔茨海默病(AD)是严重危害中老年人健康的神经系统退行性疾病,积极寻求防治AD的有效策略,已经成为重大的公共卫生问题。银杏叶提取物银杏叶提取物(EGb)是目前临床防治AD的常用药物之一,并且具有较为理想的效果。EGb761可保护血脑屏障结构与功能,其机制与EGb761改善细胞活力、抑制细胞凋亡与内源性活性氧生成和下调晚期糖化终产物受体表达等密切相关;EGb可明显促进热休克蛋白70和葡萄糖调节蛋白表达,激活内质网应激和Akt信号通路,从而抑制β-淀粉样蛋白(Aβ)的神经毒性,保护神经,以免受损。本文对EGb在防治AD中的作用与机制研究的新进展进行综述。
Alzheimer＇s disease （AD） is a serious nervous system degenerative disease, which damages to the health of middle-aged and elderly people. It is a major public health problem to seek effective strategies for prevention and treatment of AD. Ginkgo biloba extract （EGb） is one of the common drugs to prevent and to treat AD and has an ideal effect. EGb761 has protective effects on the structure and function, which may be related to the decrease in AI3-trig- gered cell injury, cells apoptosis and intracellular reactive oxygen species generation, and down-expression of receptor for advanced glycation end-products. EGb has neuroprotective effects, which may be related to endoplasmic reticulum stress activation and upexpression of HSPTO and GRP78 expression, and subsequent activation of Akt signaling pathway. The novel progress of effects and mechanisms of EGb for the prevention and treatment of AD was summarized in the present paper.
出处
《中国医药导报》
CAS
2016年第12期61-64,共4页
China Medical Herald
