慢性肾脏病住院患者降压药物的使用评价

Investigation of Oral Antihypertensive Drugs in Hospitalized Chronic Kidney Disease Patients

目的：回顾性调查慢性肾脏病合并高血压住院患者降压药的使用,为临床合理用药提供依据。方法：调查2014年（1-12月）我院肾内科慢性肾脏病合并高血压住院患者共196例,对其使用降压药情况进行统计分析。结果：67.35%患者使用联合降压方案,其中30.61%的患者两药联用,21.94%的患者三药联合。在降压药的选择上,使用频率最高的为RAS阻断剂（包括ACEI和ARB）,占78.57%;其次为钙离子拮抗剂类降压药,占66.84%。血压达标率为57.65%（113/196）。发现1例降压药物相关的不良反应。结论：慢性肾脏病的高血压患者联合应用降压药的比例很高,临床应用时应密切随访,以避免不良反应的发生。

Objective： To investigate management of hypertension in hospitalized patients with chronic kidney disease（CKD）and hypertension, and to provide references for rational use of drugs.Methods： 196 patients with CKD and hypertension who hospitalized in our hospital urology department from 2014（1-12month）were studied. Results： 67.35% patients took 2 or more antihypertensive medications, in which 30.61% of those patients with the combination of two drugs, 21.94% of those patients with the combination of three drugs. Renin-angiotensin system（RAS）inhibitors（including ACEI and ARB）were the most frequently prescribed drug, taken by 78.57% patients,followed by CCB 66.84%. The hypertension control rate was 57.65%（113/196）. We found one cases of antihypertensive drug related adverse reactions. Conclusions： A high proportion of combined use of antihypertensive drugs was found in CKD patients with hypertension, thus those patients should be closely followed up during the clinical application to avoid the occurrence of adverse reactions.