社区成年盐敏感性高血压患者血浆神经肽Y和脑钠肽水平变化的意义研究

Signiifcance of changes of plasma neuropeptide Y and brain natriuretic peptide levels in community adults with salt sensitive hypertension

目的：探讨社区成年人盐敏感性高血压的相关因素，特别是血浆神经肽Y（NPY）和脑钠肽（BNP）水平变化与盐敏感性高血压的关联。方法该研究于2014年12月至2015年10月共调查山西运城同德医院及延安大学咸阳医院管辖的社区居民1986名，发现原发性高血压患者100例，盐敏感性高血压患者65例（改良Sullivan 急性口服盐水负荷试验评定），同时从高血压患者家属中选取105名（无高血压）作为对照组。对受试者进行问卷调查，并测量身高、体重、腰围及血压，检测血清肌酐（Cr）水平、空腹血糖（FBG）、NPY以及BNP。比较3组一般情况，采用多因素Logistic回归分析盐敏感性高血压的影响因素。结果两组高血压患者的Cr、NPY以及BNP水平均高于正常对照组人群；盐敏感性高血压患者的Cr、NPY水平在3组研究对象中最高，高血压家族史的人数比例也最高，差异有统计学意义（P〈0.05）；原发性高血压患者的BNP水平最高，差异有统计学意义（P〈0.05）。随着高血压级别升高，盐敏感性高血压患者的NPY水平和BNP水平均增高，差异有统计学意义（P〈0.05）。Logistic回归模型进行分析，单因素和多因素分析结果均提示，FBG低者发生盐敏感性高血压的概率低；而NPY、BNP水平增高、血清Cr水平异常以及高血压家族史都是盐敏感高血压发生的危险因素。结论 NPY、BNP水平增高等因素均可增加盐敏感性高血压发生的概率。

Objective To study the community adult salt sensitivity the related factors of high blood pressure, especially of plasma neuropeptide Y （NPY） and brain natriuretic peptide （BNP） level changes associated with eye sensitivity of high blood pressure. Methods This study investigated the jurisdiction of the community residents of 1986 people, the survey of 100 patients with essential hypertension （eh）, salt sensitivity 65 hypertension patients （modified Sullivan, acute oral saline load test assessment）, at the same time pick up against 105 people from the hypertension patients＇ families （hypertension）. Questionnaire investigation and analysis on the measurement of height, body mass, waist circumference and blood pressure, to detect Cr level, FBG, NPY and BNP. Modified Sullivan, acute oral saline load test for salt sensitivity, residents can be divided into salt sensitivity hypertension group （n=65） with the salt sensitive hypertension group （n=100）, compare three groups in general, the multi-factor Logistic regression analysis the influence factors of high blood pressure, salt sensitivity. Results Two groups of patients with high blood pressure levels of Cr, NPY and BNP levels were higher than normal control group;Salt sensitivity of patients with high blood pressure, serum creatinine （Cr）, NPY levels in three groups in the highest, and family history of high blood pressure and the difference is statistically significant;Essential hypertension in patients with BNP level is highest, the difference was＆nbsp;statistically significant. Hypertensive patients with high blood pressure level increases, salt sensitivity of NPY levels and BNP levels are higher, there are statistically significant. Logistic regression models were analyzed, and the single factor and multiple factors analysis results suggest that FBG with a low probability of high blood pressure, salt sensitivity;And NPY levels increased, BNP levels increased, abnormal level of serum Cr, and family history of hypertension is salt sensitive hypertension risk factors. Conclusions NPY levels increased, BNP level factors all can increase the probability of the occurrence of high blood pressure, salt sensitivity.