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高迁移率族蛋白A2基因与肿瘤关系的研究进展 被引量:2

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摘要 高迁移率族蛋白A2(high mobility group A2,HMGA2)基因已被公认为是一种新的癌基因,是高迁移率族(high mobility group,HMG)蛋白超家族成员之一。大量的研究发现HMGA2与肿瘤的发生、发展、预后密切相关,甚至有望成为肿瘤基因治疗的新靶点。HMGA2在恶性肿瘤发生、发展中的作用正成为癌症研究的一个热点问题。
出处 《重庆医学》 CAS 北大核心 2016年第14期1992-1995,共4页 Chongqing medicine
关键词 肿瘤 基因 HMGA2
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参考文献36

  • 1Reeves R. Molecular biology of HMGA proteins:hubs of nuclear function[J]. Gene,2001,277(1/2) :63-81.
  • 2Reeves R,Beckerbauer L. HMGI/Y proteins:flexible reg- ulators of transcription and chromatin structure[J]. Bio- chim Biophys Acta, 2001,1519(1/2) : 13-29.
  • 3Fedele M,Fusco A. HMGA and cancer[J]. Biochim Bio- phys Acta,2010,1799(1/2) :48-54.
  • 4Morishita A, Zaidi MR, Mitoro AA, et al. HMGA2 is a driver of tumor metastasis[J]. Cancer Res, 2013,73 (14) :4289-4299.
  • 5Natarajan S, Hombach-Klonisch S, Droege PA. HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells[J]. Neoplasia, 2013,15(3) :263.
  • 6Li O, Li J, DrOge P. DNA architectural factor and proto- oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells[J]. FEBS Lett, 2007,581 (18) : 3533-3537.
  • 7王霜,刘晓力,欧阳凌云,许娜,杜庆锋,刘志,欧阳昭.实时荧光定量PCR分析CML患者HMGA2基因的表达及其临床意义[J].中国肿瘤生物治疗杂志,2010,17(2):183-189. 被引量:1
  • 8Wei J, Li H,Wang S, et al. let-7 enhances osteogenesis and bone formation while repressing adipogenesis of hu- man stromal/mesenehymal stem cells by regulating HM- GA2[J]. Stem Cells Dev,2014,23(13) :1452-1463.
  • 9Bertsch E, Qiang W, Zhang Q, et al. Medl2 and HMGA2 mutations:two independent genetic events in uterine leio- myoma and leiomyosarcoma[J ]. Mod Pathol, 2014,27 (8) : 1144-1153.
  • 10Kitchen MO, Yacqub-Usman K, Emes RD, et al. Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells [J]. Pituitary, 2015,18 ( 5 ) : 674-684.

二级参考文献22

  • 1吴德沛.慢性髓细胞白血病[M]//陆再英,钟南山.内科学.7版.北京:人民卫生出版社,2008:609-613.
  • 2陈珊珊.慢性粒细胞白血病[M]//张之南,沈悌.血液病诊断及疗效标准.3版.北京:科学出版社,2008:135-136.
  • 3Meyer B,Krisponeit D,Junghanss C,Escobar MH,Bullerdiek J.Quantitative expression analysis in peripheral blood of patients with chronic myeloid leukaemia:correlation between HMGA2 expression and white blood cell count[J].Leuk Lymphoma,2007,48(10):2008-2013.
  • 4Huang ML,Chen CC,Chang LC.Gene expressions of HMGI-C and HMGI(Y) are associated with stage and metastasis in colorectal cancer[J].Int J Colorectal Dis,2009,24(11):1281-1286.
  • 5Santulli B,Kazmierczak B,Napolitano R,Caliendo I,Chiappetta G,Rippe V,et al.A 12q13 translocation involving the HMGI-C gene in richter transformation of a chronic lymphocytic leukemia[J].Cancer Genet Cytogenet,2000,119(1):70-73.
  • 6Pierantoni GM,Santulli B,Caliendo I,Pentimalli F,Chiappetta G,Zanesi N,et al.HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia[J].Int J Oncol,2003,23(2):363-367.
  • 7Andrieux J,Demory JL,Dupriez B,Quief S,Plantier I,Roumier C,et al.Dysregulation and overexpression of HMGA2 in myelofibrosis with myeloid metaplasia[J].Genes Chromosomes Cancer,2004,39(1):82-87.
  • 8Odero MD,Grand FH,Iqbal S,Ross F,Roman JP,Vizmanos JL,et al.Disruption and aberrant expression of HMGA2 as a conxequence of diverse chromosomal translocations in myeloid malignancies[J].Leukemia,2005,19(2):245-252.
  • 9Cleynen I,Van de Ven WJ.The HMGA proteins:a myriad of functions[J].Int J Oncol,2008,32(2):289-305.
  • 10Borrmann L,Schwanbeck R,Heyduk T,Seebeck B,Rogalla P,Bullerdiek J,et al.High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity[J].Nucleic Acids Res,2003,31(23):6841-6851.

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