MMP-9、CD147、hs-CRP、IL-6对急性脑梗死伴微出血的诊断价值

The Diagnostic Values of MMP-9、CD147、hs-CRP、IL-6 for Acute Cerebral Infarction with Microbleeds

目的探讨生物学标志物对脑微出血(CMB)的诊断价值。方法应用磁共振行常规序列及磁敏感加权成像(SWI)序列探测急性期脑梗死,选入84例患者,其中无微出血组62例、合并微出血组22例,并收集同期健康体检者40例,分别检验金属蛋白酶(MMP-9)、细胞外基质金属蛋白酶诱导剂(CD147)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)水平并进行相关分析。结果合并微出血组生物学标志物水平明显高于无微出血组,且均高于同期健康体检组,差异有统计学意义(P<0.01)。Logistics回归分析显示生物学标志物水平与CMB相关,其中CD147与hsCRP检验效能最高。结论生物学标志物MMP-9、CD147、hs-CRP、IL-6与急性期脑梗死合并微出血密切相关,具有重要的诊断价值。

Objective To discuss diagnostic values of biological markers for cerebral microbleeds （CMB ） .Methods Magnetic reso-nance （MRI） line of regular sequences and magnetic sensitive weighted imaging （SWI） sequence were used to detect acute cerebral infarction.84 patients were selected and divided into two groups：non_cerebral microbleeds group（n=62） and merging cerebral mi-crobleeds group （n=22）.40 healthy cases of the corresponding period were collected.Metalloproteinases MMP_9 ,CD147 ,hyper-sensitive c_reactive protein （hs_CRP） interleukin （IL_6） were respectively tested and correlation analysis between CMB and these markers was made.Results Level of the biological markers in merging cerebral microbleeds group was significantly higher than in non_cerebral microbleeds group ,and they were both significantly higher than that in healthy check_up group ,which was statistically signif-icant （ P〈0.01）.Logistics regression analysis showed that level of specific biological markers was correlation with CMB ,power of test of CD147 and hs_CRP were higher.Conclusions MMP_9 ,CD147 ,hs_CRP ,IL_6 are closely related to acute cerebral infarction with microbleedings ,which has important diagnostic values.