摘要
目的:研究中国北方地区桦树花粉过敏及花粉–食物过敏综合征。创新点:国内首次研究花粉–食物过敏综合征,为中国北方地区此类患者的诊断和治疗提出了新思路。方法:采集临床中过敏患者血清,检测桦树花粉及其主要过敏原特异性免疫球蛋白E(IgE),同时检测大豆和苹果过敏原的特异性IgE,并评价其相关性。结论:中国北方地区桦树花粉季节对此花粉过敏的患者有16.7%以上,主要是对桦树花粉第一组过敏原致敏。这些患者大多数同时对大豆和苹果的主要过敏原过敏,这种特异性IgE高相关性说明临床上存在花粉–食物过敏综合征。
Background: Birch pollen sensitization and associated pollen-food syndrome among Chinese allergic patients have not been investigated. Methods: Sera from 203 allergic patients from the northern part of China and collected during February to July 2014 were investigated. Specific immunoglobulin E (IgE) against birch pollen extract Bet v and major birch pollen allergen Bet v 1 were measured using the ADVIA Centaur. The presence of major apple allergen Mal d 1 and soy bean allergen Gly m 4 specific IgE was measured by ImmunoCAP 100. Results: Among the 203 sere, 34 sera (16.7%) had specific IgE to Bet v and of these, 28 sere (82.4%) contained Bet v 1-specific IgE. Among the 28 sera with Bet v 1-specific IgE, 27 sera (96.4%) contained Mal d 1-specific IgE and 22 sera (78.6%) contained Gly m 4-specific igE. Of the 34 Bet v-positive sera, 6 sera (17.6%) contained no specific IgE for Bet v 1, Mal d 1, or Gly m 4. Almost all Bet v-positive sera were donated during the birch pollen season. Conclusions: The prevalence of birch allergy among patients visiting health care during pollen season can be as high as 16.7% in Tangshan City. The majority of Chinese birch allergic patients are IgE-sensitized to the major birch pollen allergen Bet v 1 as well as to the major apple allergen Mal d 1 and soy bean allergen Gly m 4. A relatively high number of patients (17.6%) are IgE-sensitized to birch pollen allergen(s) other than Bet v 1. The high prevalence of specific IgE to Mal d 1 and Gly m 4 among Bet v 1-sensitized patients indicates that pollen-food allergy syndrome could be of clinical relevance in China.
关键词
桦树
大豆
苹果
特异性IGE
花粉–食物过敏综合征
Apple, Birch, Cross-reaction, Pollen-food allergy, Soy, Specific immunoglobulin E (IgE)