反复喘息儿童的临床结局及激素疗效研究

The clinical outcome of wheezing children and the research of hormone curative effect

目的：探究反复喘息儿童的临床结局及吸入激素的治疗效果。方法选择2009年6月至2013年6月在该院因反复喘息就诊的患者86例。根据患者首次喘息发作的年龄，将患者分为5组；根据患者是否吸入激素分为吸入治疗组和未吸入治疗组；根据疗程起始年龄不同将吸入治疗组分为3组，分析以上各组间的临床控制率。结果首次喘息发作年龄≤6个月组、6个月至1岁组、1～3岁组、3～7岁组和7～12岁组患者的临床控制率分别为66．67％、72．22％、71．43％、75．00％、44．44％，不同喘息首发年龄之间临床控制率的差异有统计学意义（ P＜0．05）。吸入激素持续1年以上的患者中有35例（81．40％）哮喘未再发作，而未吸入治疗的43例患者中仅28例（65．12％）未再发作，两者的临床控制率差异有统计学意义（ P＜0．05）。结论89．53％的反复喘息儿童首次喘息发生在7岁以内，大多数可以临床控制；较长期的激素吸入治疗可降低反复喘息患者发展为成人哮喘的风险。患者吸入激素治疗的疗程起始年龄越小，喘息的临床控制率越高。

Objective To explore the clinical outcome of repeated wheezing children and the therapeutic effect of inhaled corticosteroids .Methods 86 cases of patients with repeated breathing treatment were selected from June 2009 to June 2013 in our hospital .According to patients′ age of first break attack ,the patients were divided into 5 groups ;according to whether patients with inhaled corticosteroids were divided into treatment group inhalation and not inhale treatment group;according to different courses of starting age in the treatment group was divided into 3 groups ,analysis of the above clinical control of each group .Results Wheezing onset age 6 months or less for the first time ,6 months to 1 year old ,1-3 years old group ,3-7 years old ,and 7-12 years old group of patients with clinical control rates were 66 .67% ,72 .22% ,71 .43% ,75 .00% ,44 .44% ,clinical control between different breathing starting age difference was statistically significant（P〈0 .05） .Inhaled corticosteroids for more than 1 year 35 cases（81 .40% ） asthma attack again ,not without inhalation in the treatment of 43 patients with only 28 cases（65 .12% ）did not attack again ,both clinical control difference was statistically significant（P〈0 .05） .Conclusion 89 .53% of repeated wheez‐ing breath for the first time in 7 years old children of less than ,most clinical control;Longer‐term hormone inhalation therapy can reduce the risk of repeated breathing for the development of adult asthma patients .Inhaled corticosteroid therapy in patients with treatment of starting age is smaller ,the higher the breathing clinical control .