吉西他滨联合奥沙利铂、甲泼尼龙治疗复发难治性非霍奇金淋巴瘤的疗效

Gemcitabine combined oxaliplatin into,Methylprednisolone curative effect for the treatment of recurrent refractory non-hodgkin's lymphoma

目的：研究对病情反复难治性非霍奇金淋巴瘤采用多种化疗药物联合治疗临床疗效。方法：选取本院于2014年8月~2015年8月收治的经正规治疗后复发的28例非霍奇金淋巴瘤患者,d1行吉西他滨静脉滴注,d8重复上述操作,d2行奥沙利铂100mg/m2经静脉滴注,d1行甲泼尼龙静脉滴注,d5重复。患者治疗4个周期,一个周期28d。观察临床疗效及药物不良反应。结果：本院收治的28例非霍奇金淋巴瘤患者中,疾病治愈16例（57.14%）,病情得到有效控制7例（25%）,病情无进展5例（17.86%）;患者疾病治疗总有效率为23例（82.14%）。患者行血液检查,白细胞呈下降2例、贫血4例、出现恶心呕吐3例,肝功能损害1例,不良反应发生率为10例（35.71%）。结论：临床采用吉西他滨联合奥沙利铂与甲泼尼龙治疗复发难治性非霍奇金淋巴瘤,临床疗效较明显不良反应较少。

Objective：to study of the illness repeatedly USES the many kinds of chemotherapy drugs in patients with refractory non- hodgkin＇s lymphoma of the clinical curative effect of combination therapy. Selection methods：in our hospital from 2014.8 to 2015.8 after treated by regular treatment and relapse during the period of 28 patients with non-hodgkin＇s lymphoma, 1 day line gemcitabine intravenous drip, and on the eighth day repeat the above operation, the second day line oxaliplafin into 100mg/m2 after intravenous drip, day 1 line of methylprednisolone into intravenous drip, the fifth day repeat. Treatment of patients with four cycles, a period of 28 days. The clinical curative effect and adverse drug reactions were observed. Results：Selection 28 cases admitted in our hospital in patients with non-hodgkin＇s lymphoma, 16 patients with disease cured （57.14%）, to effectively control condition for 7 cases （25%）, no progression for 5 cases （17.86%）; Disease treatment the total effective rate of 23 cases （82.14%）. Patients blood tests, white blood cells in 2 cases, anemia, 4 patients with a downward, nausea and vomiting （3 cases）, liver function damage in 1 case, the incidence of adverse reactions for 10 cases （35.71%）. Conclusion：clinical using gemcitabine combined with oxaliplatin into ,methylprednisolone non-hodgkin＇s lymphoma treatment easy recurrence, its clinical curative effect is obvious and less adverse reaction.