Th3、Th17及其相关因子在自身免疫性甲状腺疾病中的影响及其意义

Th3,Th17 and its relatedinfluential factors inautoimmune thyroiddiseases and itssignificance

目的：研究Th3、Th17及其相关因子在自身免疫性甲状腺疾病中的影响及其意义。方法：选取2012年9月~2013年9月于我院就诊的50例初诊弥漫性毒性甲状腺肿（GD）患者,称为A组;50例初诊桥本甲状腺炎（HT）患者,称为B组;另选取门诊50例健康人群组成C组。A组及B组在经过系统内科治疗后,随访至甲状腺功能恢复正常。随访期间,定期检测和统计三组人群Th3、Th17及其相关因子（IL-17、TGF-β1）的水平。结果：A组患者初诊时外周血Th3细胞下降,B组患者初诊时外周血Th3细胞上升,较C组比较差异明显,具有统计学意义（P〈0.05）;A组、B组患者初诊时外周血Th17细胞升高,较C组比较差异明显,具有统计学意义（P〈0.05）;A组、B组患者初诊时及治愈后血浆IL-17水平升高,较C组比较差异明显,具有统计学意义（P〈0.05）;B组患者初诊时及治愈后血浆TGF-β1水平升高,较C组比较差异明显,具有统计学意义（P〈0.05）。结论：Th3、Th17及其相关因子（IL-17、TGF-β1）与自身免疫性甲状腺疾病的发生有一定的联系,血浆TGF-β1水平还可能参与HT的发生。

Objective：To researchTh3,Th17 and its relatedinfluential factors inautoimmune thyroiddiseases and itssignifieance. Methods： Selected 40eases of GD patients, called the Agroup;40cases of HT patients, called the Bgroup; 40 healthy people, called the Cgroup. Follow up of the Agroup,B groupuntil a cure.Detection of threegroupsof Th3 ,Thl7 and its related factorsof regular （IL-17 ,TGF-β1 ） levels,records andstatistics. Results：Group Apatients withTh3 cells decreased, in peripheral blood ofpatients withrisingB group, significantly higher than Cgroup differences （P 〈0.05）;group A, group Bpatients withperipheralblood Thl7 cells in creasedsignificantlycompared with C group （P〈0.05）;group A,group Bpatients withelevated plasma IL-17 levelsand after healing,was higher in group C thanthe differences （P〈0.05）;group Bpatients withthe treatment andplasma TGF-β1 levels,significantly higher than Cgroup differences （P〈0.05）.Conclusion：Th3,Thl7 and its related factors （IL-17,TGF-β1）associated with theoccurrenceof autoimmune thyroid disease, plasmaTGF-β1 level mayparticipate in HT.