摘要
雷公藤甲素是从雷公藤中提取的环氧化二萜内酯化合物,对卵巢癌体外培养细胞及体内实体瘤均有显著的抑制作用,并可有效抑制耐顺铂卵巢癌细胞的生长。综合近年来国内外对雷公藤甲素抗卵巢癌的最新研究结果,对雷公藤甲素抗卵巢癌的作用及其诱导卵巢癌细胞凋亡、干预细胞周期、抑制癌细胞转移等方面的机制进行综述。
Triptolide is an epoxidated diterpene lactone compound separated from Tripterygium wilfordii. It has been reported that triptolide inhibits the growth of ovarian cancer cells in vitro and suppresses tumor growth in vivo. Triptolide could also sensitize ovarian cancer cells to cisplatin. Having combined the latest literatures on the effects of triptolide on ovarian cancer domestic and abroad, this article reviews the recent research advances in the anti-ovarian cancer activity of triptolide and its mechanisms which include inducing apoptosis of ovarian cancer cells, interfering in the cell cycle, and suppressing cell metastasis.
出处
《中草药》
CAS
CSCD
北大核心
2016年第6期1049-1052,共4页
Chinese Traditional and Herbal Drugs
基金
高等学校博士学科点专项科研基金项目(20133237120011)
江苏高校优势学科建设工程资助项目
关键词
雷公藤甲素
卵巢癌
细胞凋亡
细胞周期
癌细胞转移
作用机制
triptolide
ovarian cancer
cell apoptosis
cell cycle
cancer cell metastasis
mechanism of action
