男性非糖尿病人群维生素D与血糖关系研究

Relationship between serum level of 25-hydroxyvitamin D and fasting blood glucose in males without diabetes

目的探讨非糖尿病人群维生素D与血糖之间的相关性。方法选取2013年1-12月在解放军306医院体检中心体检的男性620例,留取空腹静脉血,测定血清25-羟维生素D[25(OH)D]水平,并检测空腹血糖(FBG)。根据25(OH)D水平进行三分变量法分组,分别分为低分位、中分位和高分位3组,分析25(OH)D水平与FBG之间的关系。结果低分位组的FBG[(5.19±0.39)nmol/L]明显高于中分位组[(5.07±0.41)nmol/L]和高分位组[(5.07±0.35)nmol/L],组间比较,差异有统计学意义(P<0.01)。血清25(OH)D水平与FBG呈明显负相关(r=-0.12,P<0.01)。结论男性非糖尿病人群维生素D水平与FBG密切相关,维持人体正常维生素D水平可能对预防糖尿病的发生、降低糖尿病的患病率起到一定作用。

Objective To explore the correlation between serum vitamin D level and fasting blood glucose in males without diabetes. Methods A retrospective study was performed on 620 cases of male patients examined in No. 306 hospital of PLA from January to December in 2013. Clinical index such as serum 25-hydroxy vitamin D[25（OH）D] level and fasting blood glucose（FBG）were exam-ined and analized. Based on the level of serum 25 （ OH ） D, all the participants were divided into the lowest 25 （ OH ） D tertile group（19. 00~41. 98 nmol/L）,the middle tertile group（41. 99~58. 00 nmol/L）and the highest 25（OH）D tertile group（58. 01~142. 00 nmol/L）. Results The FBG in the lowest 25（OH）D tertile group[（5. 19 ± 0. 39）nmol/L] was significantly higher than that in the middle tertile group[（5. 07 ±0. 41）nmol/L,P〈0. 01）]and the highest 25（OH）D tertile group[（5. 07 ±0. 35）nmol/L,P〈0. 01）]. Moreover,serum 25（OH）D level was significant inverse correlated to FBG（r=-0. 12,P〈0. 01）. Conclusion The serum vitamin D level is closely related to the FBG in males without diabetes. To maintain body′s normal level of vitamin D may prevent or reduce the incidence of diabetes.