载脂蛋白E基因多态性与浙江省泰顺县畲族患者脑梗死的相关性研究

Correlation between apolipoprotein E gene polymorphism in Yu patients and cerebral infarction in Taishun county of Zhejiang province

目的：探讨载脂蛋白 E 基因多态性与浙江省泰顺县司前镇畲族患者脑梗死的相关性。方法测定泰顺县司前镇畲族脑梗死患者112例（脑梗组）和健康体检者88例（对照组）进行 apoE 的基因多态性分析，并对脑梗死患者进行入院后各时间段的 NIHSS 评分。结果脑梗组和对照组中均为 apoEε3／3基因型最多，分别为70．5％（79／112）和63．6％（56／88），两者差异无统计学意义（P ＞0．05）；脑梗组和对照组中均为apoEε3最多，分别为82．1％（92／112）和75．6％（66．5／88），两者差异无统计学意义（P ＞0．05）。脑梗组ε4为9．8％（11／112），显著高于对照组的4．0％（3．5／88）；ε2为6．2％（7／112），显著低于对照组的19．3％（17／88），差异均有统计学意义（χ^2＝6．189、7．970，均 P ＜0．05）。携带 apoEε4的脑梗患者在入院时、入院7 d 及14 d 的各时间段 NIHSS 评分均较未携带ε4患者显著升高（t ＝7．853、6．185、5．165，均 P ＜0．05）；而在各个时间点携带ε2基因的患者与未携带ε2的患者之间 NIHSS 评分差异无统计学意义（P ＞0．05）。结论脑梗死患者 apoE 基因多态性和病情进展及预后关系密切，apoEε4为泰顺司前镇畲族脑梗死患者易感因素。同时检测 apoE 基因型与 NIHSS 评分有助于患者的预后判断。

Objective To explore the relationship between apolipoprotein E gene polymorphism and cerebral infarction in Taishun county.Methods Determination of 112 cases of Taishun Siqian cerebral infarction patients and healthy persons 88 cases of ApoE gene polymorphism,and the cerebral infarction patients were admitted to the hospital＆amp;nbsp;for different period of time after the NIHSS score.Results The cerebral infarction group and the control group were ApoE -/3 genotype most were 70.5%（79 /112）and 63.6%（56 /88）,both had significant difference（P 〉0.05）;The cerebral infarction group and the control group in terms of ApoE -up to 3,respectively 82.1%（92 /112）and 75.6%（66.5 /88）,both had no significant difference （P 〉0.05）.The cerebral infarction group epsilon 4 to 9.8%（11 /112）,and was significantly higher than that of the control group 4.0%（3.5 /88）;E2 was 6.2% （7 /112）, which was significantly lower than that of the control group [19.3% （17 /88）],the differences were significant （χ^2 =6.189,7.970,all P 〈0.05）.Carrying ApoE -4 of the cerebral infarction patient each time period at the time of admission,admission 7d and 14d NIHSS scores were not carrying epsilon 4 patients increased significantly （t =7.853,6.185,5.165,allP 〈0.05）;and at each time point carrying epsilon 2 gene in patients with and without carry-ing epsilon 2 patients NIHSS scores had no significant difference （P 〉0.05 ）.Conclusion Cerebral infarction patients ApoE gene polymorphism and disease progression and prognosis are closely related,ApoE -4 Taishun Siqian cerebral infarction patients predisposing factors.At the same time,the detection of apoE genotype and NIHSS score is helpful to the prognosis of the patients.