阿司匹林联合氯比格雷治疗进展性脑梗死的临床研究

Clinical study of aspirin combined with clopidogrel in the treatment of progressive cerebral infarction

目的研究阿司匹林联合氯比格雷治疗进展性脑梗死患者的疗效。方法选择我院2014年1月1日至2015年6月30日收治的进展性脑梗死患者120例，根据治疗方案分为观察组和对照组各60例，对照组单用阿司匹林治疗，观察组联用阿司匹林与氯吡格雷。对比两组患者血常规和凝血功能、NFDS评分、治疗效果与不良反应。结果两组治疗前后血小板、凝血酶原时间和活化部分凝血激酶时间对比均无统计学差异；观察组患者治疗后不良反应的总发生率为10．00％，高于对照组，但差异无统计学意义；观察组治疗后NFDS评分为（5．6±1．3），明显低于对照组；观察组治疗后总有效率为91．67％，明显高于对照组。结论阿司匹林联合氯比格雷治疗进展性脑梗死具有较好疗效，安全性较高，可提高患者生存质量。

Objective To study the clinical effect of aspirin combined with clopidogrel in the treatment of patients with progressive cerebral infarction. Methods 120 cases of progressive cerebral infarction in our hospital from January 1, 2014 to June 30, 2015 were randomly divided into observation group and control group, 60 cases in each group. Control group was only given aspirin for treatment, and observation group was given aspirin combined with clopidogrel. Compared blood routine examination, coagulation function, NFDS score, clinical efficacy, and adverse reactions of two groups. Results There were no statistically significant differences in platelet, prothrombin time （PT）, activated partial thromboplastin time （APTT） before and after treatment in both two groups; the incidence of adverse reactions after treatment in observation group was 10%, slightly higher than that in control group, without statistically significant difference between two groups; NFDS score after treatment in observation group was （5.6：~1.3）, significantly less than that in control group; the total effective rate in observation group was 91.67%, significantly higher than that in control group. Conclusion The combination of aspirin and clopidogrel in the treatment of progressive cerebral infarction has good curative effect, high safety, which can improve the quality of life of patients.