氯吡格雷联合小剂量阿司匹林在降低心肌梗死患者病死率中的作用

The effect of clopidogrel combined with low-dose aspirin in reducing the case fatality rate of myocardial infarction patients

目的探讨氯呲格雷联合小剂量阿司匹林治疗心肌梗死的临床疗效。方法回顾分析本院2011年6月至2013年12月收治的120例心肌梗死患者临床资料，随机将其分为观察组（n=60）与对照组（n=60），对照组给予常规药物治疗基础上加入小剂量阿司匹林药物进行治疗，观察组在对照组治疗基础上添加氯呲格雷治疗，比较观察组与对照组临床疗效及病死率。结果观察组与对照组患者治疗总有效率分别为93．33％、78．33％，且观察组病死率和心力衰竭、心律失常等事件发生率明显低于对照组，组间数据比较差异有统计学意义（P〈0．05）。结论氯呲格雷联合小剂量阿司匹林治疗心肌梗死患者疗效显著，能有效降低心肌梗死病死率，值得在临床上推广使用。

Objective To investigate the clinical curative effect of clopidogrel combined with low-dose aspirin in the treatment of myocardial infarction. Methods 120 patients with myocardial infarction （MI） in our hospital from June 2011 to December 2013 were randomly divided into observation group （n=60） and control group （n=60）. Control group was given low-dose aspirin on the basis of routine therapy, and observation group was given clopidogrel on the basis of control group. Compared clinical efficacy and mortality of observation group and control group. Results The total effective rate of observation group and control group were 93.33%, 78.33%, the case fatality rate, the incidence of heart failure and cardiac arrhythmia of observation group were obviously lower than those of control group, with statistically significant differences between two groups （P〈0.05）. Conclusion Clopidogrel combined with low-dose aspirin in the treatment of myocardial infarction has significant curative effect, which can effectively reduce the mortality, worthy of popularizing in clinical use.