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槲皮素药代动力学与生物活性的研究进展 被引量:13

Advances in Pharmacokinetics and Biological Activity of Quercetin
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摘要 槲皮素(quercetin,QCT)是一种主要存在于水果、蔬菜、草本植物中的黄酮类化合物,近年来广受关注。本研究就2007—2016年QCT的文献分布情况进行了初步分析,发现发文量总体呈递增趋势;并对其药代动力学以及抗癌、抗肥胖、抗阿尔茨海默病、抗抑郁和免疫调节等生物活性的研究进展进行了综述,以期为QCT的深入研究和进一步开发利用提供参考。 Quercetin(QCT) is one of the main flavonoids compounds in fruits, vegetables and herbs, and has drawn wide attention in recent years. In this paper, the distribution of literatures concerning quercetin from2007 to 2016 was analyzed. The results showed that the number of the published literatures on quercetinpresented an increasing trend. Then the research advances in pharmacokinetics of quercetin and its biologicalactivities such as anti-cancer, anti-obesity, anti-Alzheimer disease, anti-depression and immunoregulation were reviewed to provide a reference for future research and utilization of quercetin.
出处 《中国农学通报》 2016年第13期177-181,共5页 Chinese Agricultural Science Bulletin
基金 湖南省研究生科研创新项目"槲皮素对伏马毒素B1致小鼠肝细胞氧化损伤的干预作用与机制研究"(CX2015B257) 湖南农业大学大学生科技创新基金项目"槲皮素对烟曲霉毒素致小鼠肝细胞损伤的保护作用研究"
关键词 槲皮素 文献计量 药代动力学 生物活性 quercetin literature metrology pharmacokinetics biological activity
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  • 1Manach C, Scalbert A, Morand C, et al. Polyphenols: food sources and bioavailability[J]. Am. J. Clin. Nutr., 2004, 79(5):727-747.
  • 2朱红岗,凌明.大鼠体内槲皮素的血药浓度测定及其药代动力学研究[J].中国药业,2013,22(2):14-15. 被引量:15
  • 3Wein S, Wolffram S. Oral bioavailability of quercetin in horses[J]. J Equine Vet Sci, 2013, 33 (6) :441-445.
  • 4Moon Y J, Wang L, DiCenzo R, et al. Quercetin pharmacokinetics in humans[J]. Biopharm. Drug Dispos, 2008, 29(4):205-217.
  • 5程军,于治国,毕开顺.脑得生丸中中药成分红花的药效成分槲皮素在兔体内的药代动力学研究[J].中华临床医药杂志(北京),2004,5(1):25-27. 被引量:2
  • 6Zhen O Y, Xu C, Yuan W, et al. Pharmacokinetic study of rutin and quercetin in rats after oral administration of total flavones of mulberry leaf extract [J]. Rev Bras Farmacogn, 2013, 23(5): 776-782.
  • 7邓晓慧,宋海岩,张东军.槲皮素对乳腺癌细胞增殖及Survivin表达的影响[J].中国医院药学杂志,2013,33(12):965-967. 被引量:13
  • 8Pan H C, Jiang Q, Yu Y, et al. Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells[J]. Neurochem Int, 2015, 80:60-71.
  • 9Sharmila G, Bhat F A, Arunkumar R, et al. Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in?vivo model[J]. Clin Nutr, 2014, 33(4):718-726.
  • 10Lee S H, Lee E J, Min K H, et al. Quercetin enhances chemosensitivity to gemcitabine in lung cancer cells by inhibiting heat shock protein 70 expression[J]. Clin Lung Cancer, 2015, 16(6):235-243.

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