乙型肝炎病毒相关性肾炎发病机制的研究进展

Progress of research on pathogenesis of hepatitis B virus-associated glomerulonephritis

乙型肝炎病毒相关性肾炎(HBV-GN)是指由乙型肝炎病毒感染后引起的肾小球肾炎,是我国常见的继发性肾小球肾炎之一,多发于儿童及中青年人,男性多见。HBV-GN的发病机制目前尚不清楚,可能与病毒、宿主及环境因素的相互作用有关。近年来,关于乙型肝炎病毒基因及其其他分子生物学方面的研究取得了一些重要进展,本文将对此进行综述,以期对HBV-GN诊断和治疗提供新的方向和理论依据。

In China,hepatitis B virus-associated glomerulonephritis（ HBV-GN） is a common secondary glomerulonephritis caused by hepatitis B virus,which is mostly seen in male children and young adults. The pathogenesis of HBV-GN is not clear yet,which may be related with the interactions among virus,host,and environmental factors. Recently,some important progress has been made in the study on hepatitis B virus gene and its other molecular biology aspects,which has been reviewed in this paper,aiming to provide new direction and theoretical basis for its diagnosis and treatment.