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肝豆状核变性的MRI诊断与临床相关分析 被引量:1

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摘要 肝豆状核变性(HLD)又称威尔逊氏病(WD),是一种铜代谢异常的常染色体隐性遗传疾病[1],主要由第13号染色体上基因突变或缺陷导致。HLD患者体内游离铜离子不能被铜蛋白结合,过量铜离子在患者肝脏、大脑和角膜等部位沉积产生毒性,引起患者各系统功能异常改变[2-3]。如早期诊断及时治疗,效果良好[4]。
出处 《贵州医药》 CAS 2016年第4期405-406,共2页 Guizhou Medical Journal
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参考文献12

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二级参考文献12

  • 1梁秀龄,陈曦,李洵桦,黄丽,石铸,汤其强.肝豆状核变性临床若干问题[J].中华神经科杂志,2005,38(1):57-59. 被引量:53
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  • 9Brewer GJ, Hedera P, Khin KJ, et al. Treatment of Wilson disease with ammonium tetrathiomolybdate: Ⅲ. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy. Arch Neurol, 2003,60: 379-385.
  • 10Brewer GJ. Novel therapeutic approaches to the treatment of Wilson's disease. Expert Opin Pharmacother, 2006, 7: 317-324.

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