MicroRNA基因调控在膝骨关节炎发生发展作用中的研究进展

Progress on the regulation of MicroRNA gene on the pathogenesis of knee osteoarthritis

MicroRNA(miRMA)是一种从哺乳动物细胞内发现的非编码小分子RNA,在基因的表达调控中起到了非常重要的作用,特别是转录后调节机制方面。近年来,miRNA在疾病发生发展过程中的作用已经成为研究热点。膝骨关节炎是一种常见的老年性疾病,其病因及发病机制至今尚未完全明确,目前细胞因子通过调节炎症反应,成骨破骨细胞增值、凋零、分化在膝骨关节炎发病机制中的作用越来越受到关注。而最新的研究表明,炎性介质、成骨破骨细胞增殖分化及各种细胞因子的转录表达都与miRNA有着密切的关联,这提示miRNA在膝骨关节炎的发生发展中起重要作用。由此可以想到,通过改变相关miRNA的表达可能会从更高的调节水平改变膝骨关节炎的表达,从而起到了治疗的目的。本文正是基于MicroRNA基因调控,探讨膝骨关节炎的发病机制,为临床提供更多的治疗思路。

MicroRNA（miRMA） is a kind of small non coding RNA molecules discovery from mammalian cells,plays a very important role in the regulation of gene expression,especially the regulation mechanism of post transcriptional aspects.In recent years,the role of miRNA in the initiation and progression of the disease has become a research hotspot.Knee osteoarthritis is a common disease of old age,its etiology and pathogenesis is still not completely clear,at present cytokines by modulating the inflammatory reaction,osteoblast osteoclast differentiation and value-added,withered,role in the pathogenesis of osteoarthritis of the knee is more attention.The latest research suggests that inflammatory mediators,transcriptional bone osteoclasts differentiation and proliferation and various cytokines expression are closely associated with the miRNA,it suggests that miRNA plays an important role in the occurrence and development of osteoarthritis of the knee.It can be thought of by changing the expression of miRNA may be related to change knee osteoarthritis expression from higher level regulation,which played the purpose of treatment.This paper is based on the regulation of MicroRNA gene to explore the pathogenesis of knee osteoarthritis and provide more thinking for clinical treatment.