血栓通注射液联合依帕司他和甲钴胺注射液治疗糖尿病周围神经病变的疗效观察

Clinical observation of Xueshuantong Injection combined with epalrestat and Mecobalamin Injection in treatment of diabetic peripheral neuropathy

目的探讨血栓通注射液联合依帕司他和甲钴胺注射液治疗糖尿病周围神经病变的临床疗效。方法选取2013年4月—2015年8月在海南省万宁市人民医院接受治疗的糖尿病周围神经病变患者144例,随机分为对照组(70例)和治疗组(74例)。对照组口服依帕司他片,50 mg/次,3次/d;同时静脉滴注甲钴胺注射液,0.5 mg加入生理盐水200 m L,1次/d,3次/周。治疗组在对照组治疗基础上静脉滴注血栓通注射液,2 m L溶于生理盐水250 m L,1次/d。两组均连续治疗8周。观察两组的临床疗效,同时比较两组患者治疗前后正中神经、腓神经的运动神经和感觉神经传导速度的变化情况。结果治疗后,对照组和治疗组的总有效率分别为81.43%、90.54%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者正中神经、腓神经的运动神经和感觉神经传导速度均较治疗前有明显增加,同组治疗前后差异有统计学意义(P<0.05);治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论血栓通注射液联合依帕司他和甲钴胺注射液治疗糖尿病周围神经病变具有较好的临床疗效,能明显改善患者神经传导速度,且在治疗过程中未发现严重的不良反应,具有一定的临床推广应用价值。

Objective To investigate the effect of Xueshuantong Injection combined with epalrestat and Mecobalamin Injection in treatment of diabetic peripheral neuropathy. Methods Patients （144 cases） with diabetic peripheral neuropathy in Wanning People’s Hospital of Hainan Province from April 2013 to August 2015 were randomly divided into control （n=70） and treatment （n=74） groups. The patients in the control group were po administered with Epalrestat Tablets, 50 mg/time, three times daily, and they were iv administered with Mecobalamin Injection, 0.5 mg added into normal saline 200 mL, once daily, three times weekly. The patients in the treatment group were iv administered with Xueshuantong Injection on the basis of the control group, 2mL added into normal saline 250 mL, once daily. The patients in two groups were treated for 8 week. After treatment, the efficacy was evaluated, and the conduction velocity of movement and sensory nerve of median nerve and peroneal nerve in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 81.43% and 90.54%, respectively, and there were differences between two groups （P 〈 0.05）. After treatment, the conduction velocity of movement and sensory nerve of median nerve and peroneal nerve in two groups were significantly increased, and the difference was statistically significant in the same group （P 〈 0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups （P 〈 0.05）. Conclusion Xueshuantong Injection combined with epalrestat and Mecobalamin Injection has clinical curative effect in treatment of diabetic peripheral neuropathy, and can significantly improve nerve conduction velocity, and there was no serious adverse reactions in the process of treatment, which has a certain clinical application value.