长链非编码RNA在骨关节炎与骨肿瘤领域的研究进展

Research progress in the correlation between long non-coding RNAs and bone and joint disease

长链非编码RNAs（long noncoding RNAs,lnc RNAs）是基因组的一种新型转录本,lnc RNAs的发现是分子生物学、表观遗传学和基因组学等领域的重要研究进展。尽管lnc RNAs几乎无蛋白质编码功能,但大量研究证据表明,lnc RNAs调节失常、表达紊乱可导致肿瘤、免疫和神经功能失调等疾病发生[1]。近来也有证据提示,表观遗传调控在骨与关节疾病如骨关节炎、骨肿瘤、

Long noncoding RNAs （ lncRNAs ） are the vast majority of noncoding RNAs in mammalian genome. Long noncoding RNAs are involved in gene expression via chromatin remodeling, transcriptional and post transcriptional regulation. Recently, aggregated studies indicate that plenty of lncRNAs in bone and joint disease are differently expressed and deeply involved in many pathological changes. In this review, we focus on the molecular mechanisms of lncRNAs and the role of lncRNAs in the pathogenesis of bone and ＆ joint disease.