血清脂质运载蛋白-2对冠心病的临床意义

The clinical value of serum Huocalin-2 in coronary heart disease

目的检测冠心病患者血清脂质运载蛋白-2（Lipocalin-2）浓度水平，探讨脂质运载蛋白-2在冠心病中的临床意义。方法用酶联免疫反应方法检测冠心病患者167例（CHD组）及127名健康对照者（对照组）血清脂质运载蛋白-2水平，同时收集血糖、血脂等-般性资料。结果CHD组患者血清脂质运载蛋白-2浓度明显高于对照组[（417．78±55．87）pg／ml比（231．67±71．71）pg／ml，P=0．000]。相关分析表明，脂质运载蛋白-2与MDA（r=0．257，P=0．006）、hs—CRP（r=0．178，P=0．018），TNF—d（r=0．245，P=0．005）、HOMA—IR（r=0．214，P=-0．001）呈正相关，与HDL—c（r=-0．184，P=-0．027）、GSH（r=-0．358，P=0．000）呈负相关。多重线性回归分析提示，MDA、HOMA—IR是影响脂质运载蛋白-2水平的独立相关因素，血清脂质运载蛋白-2诊断冠心病ROC曲线下面积为0．812（0．765，0．861）。结论血清脂质运载蛋白-2与胰岛素抵抗、氧化应激及炎症密切相关，它有助于冠心病诊断及病情检测。

Objective To detect the serum levels of lipocalin-2 in patients of coronary heart diease （CHD）, and to analysis clinical value in coronary heart disease. Methods Enzyme linked immunosorbent assay （ELISA） was used to detect the serum lipocalin-2 in 167 CHD patients and 127 healthy controls. Results The serum Lipocalin-2 concentration in coronary heart disease was significantly higher than in healthy controls [（417.78±55.87）pg/ml vs （231.67±71.71）pg/ml, P=0.000]. Lipocalin-2 associated positively with MDA （r= 0.257, P=0.006）, hs-CRP （r=0.178, P=0.018）, TNF-a （r=0.245, P=0.005）, HOMA-IR （r=0.214, P= 0.001）, but negatively with（r=-0.184, P=-0.027）, GSH（r=-0.358, P=0.000）. The area under the receiver oper- ating characteristic curve for CHD diagnosis was estimated to Be 0.812 （0.765, 0.861 ）. Conclusion Lipocalin-2 is closely related to oxidative stress, inflammation and insulin resistance in CHD. It is useful for disease surveil- lance and diagnosis of CHD by serum lipoealin-2.