氧化型低密度脂蛋白、单核细胞趋化蛋白1与脑梗死颈动脉粥样硬化的关系

The Relationship Between Oxidized Low Density Lipoprotein,Monocyte Chemotactic Protein-1 and Carotid Atherosclerosis in Patients with Cerebral Infarction

目的探讨血清氧化型低密度脂蛋白(ox-LDL)、单核细胞趋化蛋白1(MCP-1)水平与脑梗死颈动脉粥样硬化(CAS)的关系。方法选取112例急性前循环脑梗死患者为脑梗死组,49例健康体检者为对照组,均行颈动脉超声检查。脑梗死组按颈动脉内膜中膜厚度(IMT)分为IMT正常组、IMT增厚组及斑块组;其中斑块组按斑块回声性质分为强回声斑块组、混合回声斑块组及低回声斑块组。比较脑梗死组与对照组、不同类型脑梗死亚组血清ox-LDL、MCP-1的水平。结果脑梗死组血清ox-LDL、MCP-1水平高于对照组,斑块组血清ox-LDL、MCP-1水平高于IMT正常组、IMT增厚组,低回声斑块组血清ox-LDL、MCP-1水平高于强回声斑块组、混合回声斑块组,差异均有统计学意义(P<0.05)。结论脑梗死患者血清ox-LDL、MCP-1水平越高,CAS程度越重,斑块发生率越高,且以低回声斑块居多。

Aim To investigate the relationship between serum oxidized low density lipoprotein（ ox-LDL）,monocyte chemotactic protein-1（ MCP-1） and carotid atherosclerosis（ CAS） in patients with cerebral infarction. Methods112 cases of acute anterior circulation cerebral infarction were selected as the cerebral infarction group,49 cases of healthy persons were as control group,and all of them underwent carotid artery ultrasound examination. According to the carotid intima-media thickness（ IMT）,cerebral infarction group was divided into IMT normal group,IMT thickening group and plaque group. According to the plaque echo characteristics,plaque group was divided into strong echo plaque group,mixed echo plaque group and low echo plaque group. Serum levels of ox-LDL and MCP-1 were compared between cerebral infarction group and control group,and among different types of cerebral infarction subgroups. Results The serum levels of ox-LDL and MCP-1 in the cerebral infarction group were higher than those in the control group（ P〈 0. 05）. The serum levels of ox-LDL and MCP-1 in the plaque group were higher than those in the IMT normal group and the IMT thickening group（ P〈 0. 05）. The serum levels of ox-LDL and MCP-1 in the low echo plaque group were higher than those in the strong echo plaque group and the mixed echo plaque group（ P〈 0. 05）. Conclusion In patients with cerebral infarction,the higher the serum levels of ox-LDL and MCP-1,the higher the degree of CAS,the higher the incidence of plaque,and the majority of low echo plaque.