高血压脑出血不同术式治疗患者血清PCT、CRP水平变化及其临床意义

Investigate Serum Procalcitonin（ PCT ）and CRP Level in Hypertensive Cerebral Hemorrhage Patients Treated with Different Surgical and its Clinical Significance

目的：探讨高血压脑出血不同术式治疗患者血清PCT、CRP水平变化及其临床意义。方法：选取2011年1月-2012年1月期间与我院进行手术的高血压脑出血患者120例，并根据手术方式分为微创手术组（n=67）和开颅手术组（n=53）。比较2组术前和术后不同时间的血清PCT、CRP水平变化，并分析血清PCT和CRP水平的关系。结果：微创手术组血清PCT、CRP水平均于术后24小时达到峰值，分别为378．48±87．58pg／ml和28．52±5．28mg／L，开颅手术组血清PCT、CRP水平均于术后36h达到峰值，分别为582．45±147．55pg／ml和36．42±7．89mg／L，2组达峰时间和峰值比较差异有统计学意义（P〈0．05）。Pearson相关性分析结果显示高血压脑出血患者血清PCT水平与其血清CRP水平呈正相关（r=0．724，P〈0．05）。结论：微创手术治疗高血压脑出血，可更好地控制患者的血清PCT、CRP水平，且高血压脑出血患者的血清PCT与其血清CRP水平呈正相关，可在一定程度上反映患者的炎症反应状态。

Objective： To investigate serum procalcitonin（ PCT ）and CRP level in hypertensive cerebral hemorrhage patients treated with different surgical and its clinical significance. Methods： 120 hypertensive cerebral hemorrhage patients in our hospital from January, 2011 to January, 2012 were divided into minimally invasive surgery group （n = 67） and invasive surgical group （n = 53） according to operation method. Serum PCT and CRP level changes in two groups preoperative and preoperative were analyzed and relationship between serum PCT and serum CRP levels was analyzed. Results： Serum PCT and CRP levels of minimally invasive surgery group has reached its peak level 24 h postoperative, and the peak levels are （378.48 -＋87.58） pg/ml and （28.52 -＋5.28） mg/L respectively, while serum PCT and CRP levels of invasive surgical group has reached 36h postoperative, and the peak levels are （ 582.45 ± 147.55 ） pg/ml and （36.42 ± 7.89 ） mg/L respectively. Peak reaching time and peak level of two groups has statistical significant difference （ p 〈 0.05 ）. Pearson correlation analysis results show that serum PCT level of hypertension cerebral hemorrhage patients is positively correlated with ser- um CRP level （ r = 0.724, p 〈 0.05 ）. Condusion： Minimally invasive surgical treating hypertensive cerebral hemorrhage can better control patient serum PCT and CRP levels, and serum PCT level of hypertension cerebral hemorrhage patients is positively related with serum CRP level, therefore serum PCT level can reflect inflammatory reaction condition of patients in a certain extent.