超声造影评价甲状腺结节激光消融疗效的应用

Evaluation of efficacy of laser ablation of thyroid nodules by contrast-enhanced ultrasound

目的:评价超声造影在甲状腺良性结节激光消融术中的应用价值。方法:对10个甲状腺良性结节行超声引导下激光消融治疗,对病灶术前、术后15 min及术后1、3、6、9、12个月分别行二维超声、彩色多普勒超声及超声造影进行疗效评估。结果:消融前彩色多普勒血流显像在5个甲状腺结节内部及边缘检出有彩色血流信号,而超声造影在全部10个甲状腺结节内部及边缘检出有彩色血流信号,差异有统计学意义(P<0.05);激光消融结束后超声显示10个结节呈无造影剂灌注的边界清晰的无回声区,超声造影显示6个结节边缘有少量不规则的造影剂灌注的残余组织(P<0.05)。术后1、3、6、9、12个月复查结节体积较治疗前有不同程度缩小,超声造影显示结果明显优于常规彩超。结论:超声造影较常规彩超对甲状腺激光消融治疗具有优势性指导作用。

Objective：To evaluate the value of contrast-enhanced ultrasound in the laser ablation diagnosis of benign thyroid nodules. Methods：10 benign thyroid nodules underwent ultrasound-guided percutaneous laser ablation （PLA）,and contrast-enhanced ultrasound （CEUS） were evaluated in the preoperative, 15 minutes after operation and 1, 3, 6,9,12 months after the treatment respectively.The findings were compared with 2-dimensional ultrasound and color doppler ultrasound （CDUS）. Results：Before treatment, Blood flow signal was detected by CDUS in the edge and inner regions in 5 thyroid nodules, and it was detected by CEUS in all 10, the difference was statistically significant（P〈0.05）. 15 minutes after treatment, CDUS showed no contrast agent perfusion in all 10,while CEUS showed a small amount of irregular contrast agent perfusion at the edge of 6,which suggest the tissue residues（P〈 0.05）. 1, 3, 6, 9 and 12 months after the treatment,the nodules were reduced to different degrees, and the result of CEUS was significantly superior to that of CDUS. Conclusion：CEUS has advantages over CDUS in evaluating the treatment of PLA for thyroid nodule.