儿童亚急性坏死性淋巴结炎预后的危险因素分析

Risk factor analysis for the prognosis of subacute necrotizing lymphadenitis in children

目的:探讨儿童亚急性坏死性淋巴结炎(SNL)的临床特点及影响预后的危险因素。方法:回顾性分析31例经淋巴结活检确诊的儿童SNL的临床资料,分为复发组和无复发组,对性别、年龄、既往免疫系统疾病史、临床表现及实验室结果与复发的关系进行单因素和多因素分析。结果与结论:(1)31例SNL中有8例反复发作,其中1例进展为系统性红斑狼疮(SLE)。(2)复发组与无复发组既往合并其他免疫系统性疾病、确诊前发热持续时间及淋巴细胞绝对值比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示既往合并其他自身免疫系统性疾病是儿童SNL复发的独立危险因素,应重视合并其他免疫系统性疾病的患儿有复发或进展为SLE的可能性。

Objective： To analyze the clinical features and risk factors affecting the prognosis of subacute necrotizing lymphadenitis （ SNL） in children.Methods： Through retrospective analysis ,Data of 31 children with SNL diagnosed by lymph node biopsy were analyzed and they were divided into recurrent group and non -recurrent group.ANOVA and Logistic analysis were undergo on ralationship of gender , age, clinical manifestations , laboratory tests and recurrence .Results and Conclusion： （ 1 ） Eight patients were recurrent attacks , and from them 1 case with long-term progression to systemic lupus erythematosus .（2） The combination with other immune system disease , fever duration before diagnosis , absolute value of lymphocyte in recurrent group were significantly differences than those in non-recurrent group （ P 〈0 .05 ） .The Logistic regression analysis demonstrated that combination with other immune system disease was independent risk factor for recurrent SNL in children .Attention should be paid to children with other immune system diseases in which recurrent attack or progression to SLE is possible .