水通道蛋白1和血管内皮生长因子在宫颈鳞状上皮癌组织中的表达及相关性

Expressions of AQP1 and VEGF in cervical squamous cell carcinoma tissue and their correlations

目的:探讨水通道蛋白1(AQP1)和血管内皮生长因子(VEGF)在宫颈鳞状上皮癌组织中的表达及相关性。方法:应用免疫组织化学法检测41例宫颈鳞状上皮癌、55例宫颈上皮内瘤变(CIN)和22例正常宫颈组织中AQP1、VEGF的表达,探讨二者在宫颈癌组织中的表达及相关性。结果:AQP1在宫颈鳞状上皮癌、CIN的阳性率分别为90.24%、81.82%,均显著高于正常宫颈组织的40.91%(P<0.01);VEGF在宫颈鳞状上皮癌、CIN的阳性率分别为100.00%、96.36%,显著高于正常宫颈组织的63.64%(P<0.01);AQP1在宫颈鳞状上皮癌和CIN组织中的表达差异无统计学意义(P>0.05),而宫颈鳞状上皮癌组织中VEGF表达均明显高于CIN组织(P<0.01);AQP1、VEGF的表达与宫颈鳞状上皮癌患者的年龄和组织学分化程度间差异均无统计学意义(P>0.05);AQP1和VEGF的表达呈明显正相关关系(P<0.01)。结论:AQP1和VEGF在宫颈鳞状上皮癌和CIN组织中表达上调,可能与宫颈鳞状上皮癌的发生、发展有一定关系。

Objective： To investigate the expressions of aquaporin1（ AQP1） and vascular endothelial growth factor（ VEGF） in cervical squamous cell carcinoma tissue and their correlations. Methods： The expressions of AQP1 and VEGF in 41 samples of cervical squamous cell carcinoma tissues,55 samples of cervical intraepithelial neoplasisa（ CIN） tissue and 22 samples of normal cervical tissue were detected by immunohistochemical method,and their correlations were analyzed. Results： The positive rates of AQP1 in cervical squamous cell carcinoma tissue and CIN tissue were 90. 24% and 81. 82%,respectively,which was higher than that in normal cervical tissue（ 40. 91%）（ P〈0. 01）. The positive rates of VEGF in cervical squamous cell carcinoma tissue and CIN tissue were 100. 00%and 96. 36%,respectively,which was significantly higher than that in normal cervical tissue（ 63. 64%）（ P〈0. 01）. The differences of the expressions of AQP1 and VEGF between cervical squamous cell carcinoma and CIN tissue were not statistically significant（ P〈0. 05）. The differences of the expressions of AQP1 in different ages and histological grades in cervical squamous cell carcinoma tissue were not statistically significant（ P〈0. 05）,the expression of AQP1 was significantly positive correlation with the expression of VEGF（ P〈0. 01）. Conclusions： The expressions of AQP1 and VEGF in cervical squamous cell carcinoma tissue and CIN tissue are upregulated,which may be related to the occurrence and development of the cervical squamous carcinoma.