还原型谷胱甘肽在慢性阻塞性肺疾病急性加重期治疗中的作用

Effect of reduced glutathione on AECOPD therapy

目的:研究还原型谷胱甘肽在治疗慢性阻塞性肺疾病急性加重期(AECOPD)中的作用。方法:70例AECOPD患者随机分为对照组及观察组,各35例。2组均于刚入院时测定8-异前列腺素F2α(8-iso-PGF2α)、C反应蛋白(CRP),并进行肺功能及血气分析检查;2组均常规抗感染、祛痰、平喘治疗1周,观察组在常规治疗基础上加用还原型谷胱甘肽。1周后复查2组血8-iso-PGF2α、CRP、肺功能及血气分析等指标,并进行统计分析。结果:治疗1周后,2组血8-iso-PGF2α及CRP均较治疗前明显降低(P<0.01),且观察组2项指标均显著低于对照组(P<0.01);2组患者治疗后肺功能及血气分析各指标均较治疗前显著改善(P<0.01),且观察组改善程度均明显优于对照组(P<0.01)。结论:还原型谷胱甘肽能够减轻AECOPD患者体内氧化应激反应,对AECOPD具有一定的辅助治疗价值。

Objective： To investigate the effects of reduced glutathione on acute exacerbation of chronic obstructive pulmonary disease（ AECOPD） therapy. Methods： Seventy AECOPD patients were randomly divided into the control group and observation group（ 35 cases each group）. The levels of 8-iso-prostaglandin-F2α（ 8-iso-PGF2α） and C reactive protein（ CRP）,pulmonary function and blood gas analysis in two groups were detected at the time of admission. Two groups were treated with conventional anti-inflammatory,expectorant and antiasthmatic for 1week,the observation group were additionally treated with reduced glutathione for 1 week. The levels of 8-isoprostaglandin-F2αand CRP,pulmonary function and blood gas analysis in two groups were detected again after 1 week of treatment,and statistically analyzed. Results： Compared with pre-treatment,the levels of 8-iso-PGF2αand CRP in two groups decreased significantly after 1 week of treatment（ P〈0. 01）,the levels of 8-iso-PGF2αand CRP in observation group were significantly lower than those in control group（ P〈0. 01）. Compared with pre-treatment,the indexes of pulmonary function and blood gas analysis in two groups were significantly improved after treatment,the improvement degree in observation group were significantly better than those in control group（ P〈0. 01）. Conclusions： Reduced glutathione can alleviate the oxidative stress response in patients with AECOPD,which has a certain adjuvant therapy value.