醒脑静注射液对急性脑梗死患者凝血功能及神经功能的影响

Effect of the Xingnaojing injection on coagulation and nerve function in patients with acute cerebral infarction

目的:探讨醒脑静注射液对急性脑梗死患者凝血功能及神经功能的影响。方法:将急性脑梗死患者90例随机分为观察组与对照组,各45例。对照组采用常规治疗方法,观察组在对照组治疗基础上加用醒脑静注射液治疗。结果:观察组患者CD34+细胞数与白细胞计数在治疗第6 d天达到高峰,均明显高于其他时间点(P<0.01);观察组患者血小板计数、丙氨酸氨基转移酶、血肌酐及D-二聚体水平在各时间点差异均无统计学意义(P>0.05);观察组患者活化部分凝血活酶时间、凝血酶原时间及纤维蛋白原水平在各时间点差异均有统计学意义(P<0.01);观察组患者治疗2、3个月后脑卒中量表评分均明显低于对照组(P<0.01)。结论:醒脑静注射液能有效调控急性脑梗死患者的凝血功能,改善神经功能,提高短期疗效。

Objective： To investigate the effects of the Xingnaojing injection on coagulation and nerve function in patients with acute cerebral infarction. Methods： Ninety patients with acute cerebral infarction were randomly divided into the observation group and control group（ 45 cases each group）. The control group were treated with routine method,the observation group were additionally treated with Xingnaojing injection based on routine method. Results： The number of CD34＋cell and white blood cell in the observation group were the highest after 6 days of treatment,which was obviously higher than those at other time-points（ P〈0. 01）. The differences of platelet count,and levels of alanine aminotransferase,serum creatinine and D-dimer in observation group at all time-points were not statistically significant（ P〈0. 05）. The differences of activated partial thromboplastin time,prothrombin time and fibrinogen level in observation group at different time-points were statistically significant（ P〈0. 01）. The NIHSS scores in observation group after 2 and 3 months of treatment were significantly lower than those in control group（ P〈0. 01）. Conclusions： The Xingnaojing injection can effectively regulate the coagulation and nerve function,and improve the short-term effects in patients with acute cerebral infarction.