新诊断2型糖尿病患者糖化血红蛋白与血清凝集素样氧化低密度脂蛋白受体1关系的研究

The relationship between hemoglobin A1c and lectin-like oxidized low-density lipoprotein receptor-1 in initial diagnosis type 2 diabetes patients

目的:检测新诊断2型糖尿病患者的血清凝集素样氧化低密度脂蛋白受体1(LOX-1)水平,探索血糖升高与LOX-1表达量之间的关系。方法:选取新诊断2型糖尿病患者68例作为观察组,并选取年龄、性别、腰围、体质量指数等相匹配的无糖尿病体检者56例作为对照组。检测2组空腹血糖、糖化血红蛋白、血脂及血清LOX-1浓度,分析糖化血红蛋白与LOX-1之间的相关性。结果:观察组患者的空腹血糖、糖化血红蛋白、LOX-1和低密度脂蛋白-胆固醇均显著高于对照组(P<0.01)。LOX-1与糖化血红蛋白呈正相关关系(P<0.01),血脂与LOX-1无相关关系(P>0.05)。多元线性逐步回归分析发现糖化血红蛋白的升高是LOX-1升高的独立危险因素(P<0.01)。结论:血糖升高可能直接导致了LOX-1的表达上调,进而启动糖尿病患者动脉粥样硬化的进程。

Objective： To explore the relationship between lectin-like oxidized low-density lipoprotein receptor-1（ LOX-1） and glucose level in initial diagnosis type 2 diabetes patients（ T2DM）. Methods： Sixty-eight initial diagnosis T2 DM patients were divided into the observation group,and fifty-six non-diabetic healthy people with the same age,sex,waist circumference and BMI as the observation group were set as the control group. The levels of fasting blood glucose（ FBG）,glycosylated hemoglobin A1c（ Hb A1c）,serum lipid and LOX-1 in two groups were tested. The relationship between LOX-1 and Hb A1 c was analyzed. Results： The levels of FBG,Hb A1 c,LOX-1 and LDL-cholesterol in observation group were significantly higher than those in control group（ P〈0. 01）. The level of Hb A1 c was positive correlation with LOX-1（ P〈0. 01）,and the level of lipids was not correlation with the LOX-1（ P〈0. 05）. Multivariate linear stepwise regression analysis showed that the Hb A1 c level increasing was the independent risk factor of the LOX-1 level increasing（ P〉0. 01）. Conclusions： High blood glucose may directly lead to the expression of LOX-1 increasing,which can initiate the atherosclerosis of diabetes.