加味当归汤治疗寒湿凝滞型原发性痛经71例

Seventy-One Cases of Primary Dysmenorrheal with Syndrome of Cold-Damp Obstruction and Stagnation Treated with Supplemented Chinese Angelica Decoction

目的:观察加味当归汤治疗寒湿凝滞型原发性痛经的临床疗效。方法:选取本院2011年1月—2014年1月收治的142例原发性痛经患者为研究对象,随机分为对照组和治疗组,每组各71例。对照组口服痛经宝颗粒,治疗组在采用加味当归汤进行治疗,观察两组患者的临床疗效以及治疗前后血清内皮素和一氧化氮(nitric oxide,NO)的含量。结果:治疗组有效率为88.73%,对照组有效率为74.64%,两组患者有效率比较,差异有统计学意义(P<0.05);两组患者治疗后血清内皮素水平均显著降低,与治疗前比较,差异均有统计学意义(P<0.05);且治疗组显著优于对照组,差异有统计学意义(P<0.05);两组患者治疗后其血清NO水平均显著升高,与治疗前比较,差异均有统计学意义(P<0.05);且治疗组显著由于对照组,差异具有统计学意义(P<0.05)。结论:加味当归汤治疗寒湿凝滞型原发性痛经患者疗效显著,且显著改善了患者血清内皮素及NO的水平。

Objective ：To observe the clinical curative effect of Supplemented Chinese Angelica Decoction on primary dysmenorrhe- al with syndrome of cold-damp obstruction and stagnation. Methods ： One hundred and forty-two patients with primary dysmenorrhe- al who were treated in our hospital between Jan. of 2011 and Jan. of 2014 were chosen as the research objects,and randomly divid- ed into the control group and the treatment group,with 71 cases in each group. Tile ones in the control group were given Yueyue- shu Granule for oral administration, while the ones in the treatment group were treated with Supplemented Chinese Angelica De- coction. Then the two groups＇ clinical curative effects,the contents of serum endothelin and nitric oxide（NO） were observed. Re- suits：The effective rate of the treatment group was 88.73%, while that of the control group was 74.64% ;And the difference be- tween them had statistical significance （P 〈 0.05 ）. After the treatment, the two groups＇ serum endothelin levels were both obvious- ly decreased, and all the differences betwee,1 them had statistical significance（P 〈 0.05 ）. The treatment group was better than the control group, and the difference between them had statistical significance（ P 〈 0.05 ）. After the treatment, the two groups＇ serum NO levels were both obviously increased,and all the differences between them had statistical significance（ P 〈 0.05 ）. The treat- merit group was much better than the control group, and the difference between them had statistical significance（ P 〈 0.05 ）. Con- clusion ：Supplemented Chinese Angelica Decoction has a remarkable clinical curative effect on primary dysmenorrheal with syn- drome of cold-damp obstruction and stagnation,can obviously improve serum endothelin and NO levels.