可溶性CD40配体与心脑血管疾病关系的研究进展

Progress on Relationship Between sC D40L and Cardiac- cerebral Vascular Disease

可溶性CD40配体(s CD40L)是一种跨膜糖蛋白,属肿瘤坏死因子家族,其是由m CD40L在蛋白水解酶的作用下裂解而成,并以三聚体的形式存在。有研究发现,s CD40L可增加动脉粥样硬化发生风险,且与心脑血管疾病的发生发展密切相关。本文综述了s CD40L与动脉粥样硬化、心血管疾病及脑血管疾病关系的研究进展,旨在为心脑血管疾病的防治提供新的思路。

s CD40 L is one kind of transmembrane glycoproteins,belongs to tumor necrosis factor family,comes from proteolytic enzyme- induced cracking of m CD40 L, mainly performs as tripolymer. Recent research found that, s CD40 L can increase the risk of atherosclerosis, is closely correlated with cardiac- cerebral vascular disease. This paper reviewed the correlations of s CD40 L with atherosclerosis,cardiovascular disease and cerebrovascular disease,in order to provide new clew for the prevention and treatment of cardiac- cerebral vascular disease.