环磷酰胺成功治疗慢性支气管炎并系统性红斑狼疮一例分析

Role of Cyclophosphamide in the Successful Treatment of Chronic Bronchitis Complicated With Systemic Lupus Erythematosus

慢性支气管炎是由于感染或非感染因素引起的气管、支气管黏膜及其周围组织慢性非特异性炎症。环磷酰胺属细胞毒性药物,可能通过抑制髓源抑制性细胞生成而减轻慢性支气管炎症状。本文报道的1例慢性支气管炎并系统性红斑狼疮患者使用环磷酰胺治疗后慢性支气管炎症状消失,提示细胞毒性药物可能对慢性支气管炎具有一定的治疗作用。

Chronic bronchitis belongs to chronic nonspecific inflammation,mainly involves trachea mucosa,bronchial mucosa and their surrounding tissues,its nosogenesis includes infectious factors and noninfectious factors. Cyclophosphamide is one kind of cytotoxic agents,may relieve the symptoms of chronic bronchitis by inhibiting the cytopoiesis of myeloid- derived suppressor cells. This paper reported a chronic bronchitis patient complicated with systemic lupus erythematosus whose symptoms of chronic bronchitis successfully disappeared after treatment of cyclophosphamide,it reminds that cytotoxic agents may have some therapeutic effects on chronic bronchitis.