摘要
基于超高效液相色谱电喷雾四极杆飞行时间串联质谱联用(UPLC-DAD-QTOF-MS)技术检出某保健酒中非法添加了一种磷酸二酯酶-5(PDE-5)抑制剂衍生物,经制备液相色谱分离纯化,采用UPLC-DADQTOF-MS、核磁共振(NMR)和红外光谱(IR)技术对其进行了分析和结构鉴定,确定其为一种新型艾地那非衍生物,国内外均未见报道。
Abstract： One suspected phosphodiesterase-5 inhibitor（ PDE-5 ） derivative was found in a kind of medicinal liquor by UPLC - DAD - QTOF - MS. Sample purification was carried out by a preparative HPLC system, and its structure was determined by NMR, IR and UPLC -DAD -QTOF -MS meth- ods. The results showed that the compound is a new aildenafil derivative which has never been repor- ted at home and abroad.
出处
《分析测试学报》
CAS
CSCD
北大核心
2016年第5期551-556,共6页
Journal of Instrumental Analysis
基金
河北省食品药品监督管理局重点科技项目(ZD2014006)
