铜盐催化β-双羰基化合物α-位氮宾转移反应

Nitrene Transfer Reaction on α-H of β-dicarbonyl Compounds Catalyzed by Copper Salt

以对氯苯磺酰胺为氮源,Ph I(OAc)_2为氧化剂,Cu(CF_3SO_3)_2为催化剂,β-双羰基衍生物为底物,于35℃用"一锅法"合成了6个α-氨基-β-双羰基化合物(3a^3f,3b^3f为新化合物),其结构经~1H NMR,^(13)C NMR和HR-ESI-MS表征。

Six α-amino-β-dicarbonyl compounds（ 3a ~ 3f,3b ~ 3f were novel compounds） were synthesized by ＂one-pot method ＂ at 35 ℃, using chlorobenzene sulfonamide as nitrogen source,Ph I（ OAc）_2as oxidizing agent,Cu（ CF_3SO_3）_2as catalyst and β-dicarbonyl compounds as substrate.The structures were characterized by^1 H NMR,^（13）C NMR and HR-ESI-MS.