摘要
以2,4-二硝基氯苯为起始原料,依次经甲胺化,选择性还原,N-酰化,环合,催化氢化,N-二羟乙基化,O-甲磺酰化,氯置换,酸化水解和成盐等10步反应合成盐酸苯达莫司汀,其结构经~1H NMR确证,总收率48.4%,纯度99.5%。
Bendamustine hydrochloride was synthesized by a ten-step reaction of amination,selective reduction,N-acylation,cyclization,catalytic hydrogenation,hydroxyethylation,O-sulfonylation,chlorination,hydrolysis and salification,using 2,4-dinitrochlorobenzen as starting material. The structure was confirmed by^1 H NMR. The total yield and purity were 48. 4% and 99. 5%,respectively.
出处
《合成化学》
CAS
CSCD
2016年第5期457-460,共4页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(21476078
20972051)
上海市科技支撑计划(12431900900
12431900902)
