慢性阻塞性肺病患者非发酵菌感染分析

Analysis of unfermenters infection in patients of chronic obstructive pulmonary disease

目的 探讨慢性阻塞性肺病 (COPD)急性发作患者肺部非发酵菌感染和耐药情况。方法 对我院 1999～ 2 0 0 1年 COPD患者痰培养分离出非发酵菌种类及药敏情况进行回顾性分析。结果 10 6例 COPD患者痰标本中共分离出 15 2株细菌 ,其中非发酵菌 6 3株 (41.5 % )。非发酵菌中假单胞菌 38株 ,不动杆菌 2 5株 ,对氨苄西林的耐药率达 86 .2 %、79.3% ,对头孢唑林的耐药率达78.2 %、5 8.4 % ,对喹诺酮类抗生素的耐药率达 6 7.3%、5 6 .4 %。结论 COPD患者肺部非发酵菌感染耐药严重 。

Objective To analyze the data of unfermenters infection and their antibiotic resistance in acute respiratory infection patients with chronic obstructive pulmonary disease (COPD). Methods Retrospective surveys were carried out and the data were examined for unfermenters infection and antibacterial sensitivity test results for patients with COPD between the years of 1999 and 2001. Results 152 strains of bacteria were isolated from sputum samples of 106 cases. Among them 63 strains were unfermenters (41.5%), including 38 strains of pseudomonas and 25 strains of acinetobacters. The resistance rates of pseudomonas, acinetobacters to ampicillin were 86.2%, and 79.3%; of cefazolin: 78.2%, 58.4%; of quinolind antibiotics 67.3%, and 56.4%, respectively. Conclusion The antibiotic resistances of unfermenters infection is a severe condition more effective antibiotics were needed in controlling the respiratory infection of patients with COPD.