阻塞性睡眠呼吸暂停低通气综合征相关性高血压患者血清胱抑素C和超氧化物歧化酶水平的变化

Clinical Investigation for Blood Levels of Cystetine C and Superoxide Dismutase in Patients With Obstructive Sleep Apnea Syndrome Related Hypertension

目的:观察阻塞性睡眠呼吸暂停低通气综合征(OSAS)相关性高血压患者血清胱抑素C(cystatine,CysC)和超氧化物歧化酶(Superoxide dismutase,SOD)水平的变化。方法:收集2013-01至2013-12在甘肃省人民医院心内科和鼾病科就诊并完成多导睡眠监测的高血压患者102例,根据呼吸暂停低通气指数(Apnea hypopnea index,AHI)将102例高血压患者分成2组:AHI≥5次/h的纳入OSAS相关性高血压组,即OH组55例,AHI<5次/h的纳入单纯高血压组,即高血压组47例。另选取同时间段内完成多导睡眠监测的健康人45名作为对照组。对所有研究对象进行一般情况、生化指标、睡眠参数方面数据的整理,采用SPSS17.0软件分析并比较3组上述指标间差异是否有统计学意义。结果:与对照组比较,OH组、高血压组的血清CysC水平[(1.06±0.27)mg/L和(0.91±0.19)mg/L vs(0.79±0.32)mg/L]明显升高,血清SOD水平[(127.63±63.19)U/ml和(149.14±60.12)U/ml vs(181.54±59.37)U/ml]明显下降,组间比较差异均有统计学意义(P均<0.05)。进一步将OH组按OSAS病情分为轻度者、中度者、重度者3个亚组,并将3个亚组结果进行比较可见,血清CysC、SOD在轻度和中度、轻度和重度以及中度和重度间比较,差异均无统计学意义(P均>0.05)。结论:高血压组和OH组血清CysC水平高于对照组,而血清SOD水平低于对照组;且OH组血清CysC水平高于高血压组,血清SOD低于高血压组(P<0.05),但其水平变化与OSAS病情程度的关系尚未证实。

Objective： To observe blood levels of cystetine C（CysC） and superoxide dismutase（SOD） in patients with obstructive sleep apnea syndromes（OSAS） related hypertension（HP）. Methods： A total of 102 HP patients received polysomgography（PSG） in our hospital from 2013-01 to 2013-12 were studied. According to apnea hypopnea index（AHI）, the patients were divided into 2 groups： OSAS with HP（OH） group, n=55 patients with AHI≥5 and HP group, n=47 patients with AHI〈5; in addition, there was a Control group, n=45 normal subjects with PSG examination at the same period. The general conditions, biochemical and sleep parameters were studied, the differences among 3 groups were analyzed by SPSS 17.0 software. Results： In OH group, HP group and Control group, blood levels of CysC were（1.06 ± 0.27） mg/L,（0.91 ± 0.19） mg/L and（0.79 ± 0.32） mg/L respectively; SOD were（127.63 ± 63.19） U/mL,（149.14 ± 60.12） U/mL and（181.54 ± 59.37） U/mL respectively, all P〈0.05. Based on clinical conditions, OH group was further divided into Mild, Moderate and Severe sub-groups, blood levels of CysC and SOD were similar among different sub-groups, P〉0.05.Conclusion： Blood levels of CysC in OH and HP groups were higher than Control group, CysC in OH group was higher than HP group; SOD levels in OH and HP groups were lower than Control group, SOD in OH group was lower than HP group. The relationships between CysC, SOD and OH severity were unclear.